Table 3.

Associations between allergy, allergy type, number of types of allergies and age at onset of allergies and risk of low-grade glioma

AllergiesCases with low-grade tumors (n = 75)Hospital-based controls (n = 612)aadjORb (95% CI), low grade vs. controls
Any allergy20 (26.7)282 (46.1)0.44 (0.25–0.76)
Seasonal allergy16 (21.3)243 (39.8)0.40 (0.22–0.73)
Medication allergy10 (13.3)162 (26.6)0.49 (0.24–1.00)
Pet allergy8 (10.7)107 (17.6)0.39 (0.18–0.87)
Any food allergy2 (2.7)61 (10.0)0.21 (0.05–0.91)
Other allergy6 (8.0)105 (17.3)0.39 (0.16–0.95)
Number of types of allergies
 055 (73.3)330 (54.8)Ref
 16 (8.0)62 (10.3)0.62 (0.25–1.57)
 2+14 (18.7)210 (34.9)0.39 (0.20–0.73)d
Ages at diagnosis of any allergy (among those with allergies)Cases with low- grade tumors and allergies (n = 20)Hospital-based controls and allergies (n = 271)cadjORa (95% CI) Low grade vs. controls
 <2011 (55.0)111 (41.0)Ref
 20+9 (45.0)160 (59.0)0.69 (0.14–3.34)
  • aInformation about allergy types was missing for 2 hospital controls, so the sample sizes for all allergy type analyses is 610 for controls.

  • bAdjusted for age, gender, race, education, and study site.

  • cAge at diagnosis of allergies and years since diagnosis of allergies is missing for 11 hospital controls with allergies, resulting in the sample sizes listed here.

  • dP value for trend was <0.05.