Table 2.

Associations between allergy, allergy type, number of allergies, age at onset, years since diagnosis of allergies and risk of glioma

AllergiesAll cases (n = 420)aCases with high-grade tumors (n = 344)aHospital-based controls (n = 612)aadjORb (95% CI), all cases vs. controlsadjORb (95% CI), high grade vs. controls
Any allergy140 (33.3)120 (34.9)282 (46.1)0.60 (0.46–0.79)0.66 (0.49–0.87)
Seasonal allergy
Any vs. none111 (26.6)95 (27.9)243 (39.8)0.55 (0.42–0.73)0.59 (0.44–0.80)
Number
  0306 (73.4)246 (72.1)367 (60.2)RefRef
  140 (9.6)34 (10.0)57 (9.3)0.84 (0.53–1.31)0.89 (0.56–1.42)
  231 (7.4)29 (8.5)53 (8.7)0.72 (0.45–1.17)0.83 (0.51–1.37)
  3+40 (9.6)32 (9.4)133 (21.8)0.36 (0.24–0.54)d0.37 (0.24–0.57)
Medication allergy
Any vs. none74 (17.7)64 (18.7)162 (26.6)0.68 (0.49–0.93)0.73 (0.52–1.02)
 Number
  0344 (82.3)278 (81.3)447 (73.4)RefRef
  146 (11.0)40 (11.7)82 (13.4)0.77 (0.52–1.15)0.82 (0.54–1.25)
  213 (3.1)11 (3.2)28 (4.6)0.70 (0.35–1.39)0.74 (0.35–1.53)
  3+15 (3.6)13 (3.8)52 (8.5)0.49 (0.26–0.90)0.54 (0.28–1.03)d
Pet allergy
Any vs. none51 (12.3)43 (12.7)107 (17.6)0.60 (0.41–0.88)0.68 (0.46–1.01)
 Number
  0365 (87.7)297 (87.4)501 (82.4)RefRef
  125 (6.0)22 (6.5)53 (8.7)0.65 (0.39–1.09)0.76 (0.45–1.30)
  214 (3.4)12 (3.5)15 (2.5)1.12 (0.52–2.41)1.21 (0.54–2.68)
  3+12 (2.9)9 (2.7)39 (6.4)0.34 (0.17–0.68)0.36 (0.17–0.78)
Any food allergy
Any vs. none24 (5.8)22 (6.5)61 (10.0)0.58 (0.35–0.97)0.69 (0.41–1.16)
 Number
  0392 (94.0)318 (93.3)548 (89.8)RefRef
  119 (4.6)17 (5.0)34 (5.6)0.85 (0.47–1.56)1.00 (0.54–1.86)
  2+6 (1.4)6 (1.8)28 (4.6)0.30 (0.12–0.74)d0.38 (0.15–0.96)
Other allergy
Any vs. none27 (6.5)21 (6.2)105 (17.3)0.34 (0.22–0.54)0.33 (0.20–0.55)
 Number
  0389 (93.5)319 (93.8)501 (82.7)RefRef
  120 (4.8)16 (4.7)60 (9.9)0.44 (0.26–0.75)0.43 (0.24–0.78)
  2+7 (1.7)6 (1.5)45 (7.4)0.22 (0.10–0.49)d0.19 (0.07–0.49)d
Number of types of allergies
  0280 (67.6)224 (66.3)330 (54.8)RefRef
  146 (11.1)40 (11.8)62 (10.3)0.89 (0.58–1.37)0.95 (0.61–1.49)
  250 (12.1)40 (11.8)95 (15.8)0.61 (0.41–0.90)0.61 (0.40–0.93)
  323 (5.6)22 (6.5)65 (10.8)0.45 (0.27–0.76)0.55 (0.33–0.94)
  4+15 (3.6)13 (3.6)50 (8.3)0.36 (0.19–0.67)d0.39 (0.20–0.75)d
Ages at diagnosis of any allergy (among those with allergies), yAll cases with allergies (n = 138)Cases with high-grade tumors and allergies (n = 118)cHospital-based controls and allergies (n = 271)cadjORb (95% CI), all cases vs. controlsadjORb (95% CI), high grade vs. controls
  <2064 (46.4)53 (44.9)111 (41.0)RefRef
20–3948 (34.8)42 (35.6)90 (33.2)1.19 (0.72–1.96)1.20 (0.71—-2.03)
40–7926 (18.8)23 (19.5)70 (25.8)1.05 (0.56–1.95)1.02 (0.53–1.97)
Years since diagnosis of any allergy (among those with allergies)
<1021 (15.6)19 (16.2)38 (13.5)1.24 (0.68–2.25)1.38 (0.74–2.57)
10+114 (84.4)98 (83.8)243 (86.5)RefRef
  • aAdjusted for age, gender, race, education, and study site.

  • bInformation about allergy types was missing for 3 cases with high-grade glioma and 2 hospital controls, so the sample sizes for all allergy type analyses are 341 and 610 in these groups, respectively.

  • cAge at diagnosis of allergies and years since diagnosis of allergies is missing for 2 cases with high-grade gliomas and 11 hospital controls with allergies, resulting in the sample sizes listed here.

  • dP value for trend was <0.05.