Table 2.

Ever use of metformin and the risk of prostate cancer

Metformin exposureCases (n = 739)Controls (n = 7,359)Crude RRAdjusted RR (95% CI)a
Never, n (%)203 (27.5)2,123 (28.8)1.001.00 (reference)
Ever, n (%)536 (72.5)5,236 (71.2)1.101.23 (0.99–1.52)
  • aAdjusted for HbA1c, excessive alcohol use, obesity, smoking, lower urinary tract symptoms, previous cancer, and use of NSAIDs, antihypertensive drugs, statins, and other antidiabetic agents.