Table 5.

Multivariate-adjusted HR of colon and rectal cancers in relation to fibrinogen and inflammation z-score, ARIC study, 1987–2006

Inflammatory marker (quartiles)HR (95% CI)a
Colon cancerRectal cancer
Fibrinogen, mg/dL
 ≤259ReferenceReference
 260—2941.24 (0.82–1.88)1.55 (0.79–3.03)
 295—3361.48 (0.98–2.22)1.65 (0.84–3.24)
 ≥3371.75 (1.16–2.63)0.89 (0.40–1.95)
P0.0050.84
z-score
 <−2.12ReferenceReference
 −2.12 to −0.321.41 (0.92–2.16)1.14 (0.62–2.11)
 −0.31 to 1.721.49 (0.97–2.29)0.70 (0.35–1.39)
 ≥1.732.18 (1.43–3.31)0.76 (0.38–1.53)
P0.00030.25
  • aMultivariate adjusted for age, race, center, education, BMI, aspirin use, smoking status and pack-years of smoking, diabetes, and gender–HRT at visit 1.