Table 4.

HR of CRC in relation to inflammatory markers and inflammation z-score at visit 1 in the ARIC study, 1987–2006

Inflammatory marker (quartiles)Number of CRCPerson-yearsHR (95% CI)aHR (95% CI)b
Fibrinogen, mg/dL
 ≤2595860,556ReferenceReference
 260—2947559,6131.27 (0.90–1.79)1.30 (0.91–1.85)
 295—3369056,9621.55 (1.11–2.16)1.50 (1.06–2.13)
 ≥3378553,3781.55 (1.10–2.18)1.50 (1.05–2.15)
P0.0010.03
VWF, %
 ≤836160,013ReferenceReference
 84—1098558,8271.33 (0.95–1.84)1.30 (0.93–1.84)
 110—1427357,8261.11 (0.79–1.56)1.07 (0.76–1.52)
 ≥1438953,8421.37 (0.98–1.92)1.30 (0.93–1.84)
P0.170.33
FVIII, %
 ≤1046658,721ReferenceReference
 105—1268361,3551.13 (0.82–1.57)1.13 (0.82–1.58)
 127—1507156,0761.03 (0.73–1.44)1.03 (0.73–1.46)
 ≥1518854,3571.26 (0.90–1.75)1.17 (0.83–1.65)
P0.840.54
WBC, ×109 cells/L
 ≤4.87962,251ReferenceReference
 4.9–5.86559,4280.89 (0.64–1.24)0.86 (0.61–1.21)
 5.9–7.08653,8941.32 (0.97–1.79)1.26 (0.91–1.74)
 ≥7.17854,9351.21 (0.88–1.66)1.13 (0.79–1.60)
P0.070.20
Albumin, g/dL
 ≤3.79468,412ReferenceReference
 3.84134,3950.86 (0.60–1.24)0.89 (0.61–1.29)
 3.8–3.99968,6331.05 (0.79–1.39)1.09 (0.81–1.46)
 ≥3.97459,0690.92 (0.79–1.26)0.94 (0.68–1.30)
P0.850.94
z-score
 <−2.125859,810ReferenceReference
 −2.12 to −0.327658,2401.30 (0.92–1.83)1.30 (0.91–1.84)
 −0.31 to 1.727457,6081.23 (0.87–1.75)1.19 (0.83–1.71)
 ≥1.7310054,8511.73 (1.24–2.42)1.65 (1.15–2.35)
P0.0020.01
  • aAdjusted for age, race, sex, and center.

  • bMultivariate adjusted for age, race, center, education, BMI, aspirin use, smoking status and pack-years of smoking, gender–HRT, and diabetes.