Table 5.

Associations between tumor molecular phenotype and TGFβ and Smad genes

Controls, nCases, nORa95% CI
Colon tumorsCIMP+
Smad2 rs1787199AA601641.00
 Note: Similar results for rs4940086AT/TT1,3552081.461.09–1.97
Smad3 rs2118611bAA1,2261521.00
AG/GG7291201.871.26–2.79
Smad3 rs4776892AA1,2881751.00
AT/TT667970.630.42–0.95
KRAS2 mutation
TGFβ1 rs4803455CC526741.00
CA/AA1,4572801.401.06–1.85
TGFβ1 rs1800469GG9321871.00
GA/AA1,0461660.780.62–0.98
TP53 mutation
Smad2 rs4940086TT/TC1,7624491.00
CC194671.381.02–1.86
Smad3 rs7176870AA6441461.00
AG/GG1,3113711.281.03–1.59
TGFβ1 rs4803455CC5261111.00
CA1,0142671.270.99–1.63
AA4431441.561.18–2.07
TGFβ1 rs1800469GG9322751.00
GA/AA1,0462430.780.64–0.95
MSI unstable
Smad2 rs1792689CC1,4771321.00
 Note: Similar results for rs1787199CT448451.120.79–1.60
TT3182.851.28–6.36
Smad3 rs12901071bAA/AG1,7161741.00
 Note: Similar results for rs731874GG240110.430.23–0.83
TGFβ1 rs1800469GG9321101.00
GA/AA1,046800.640.47–0.86
Rectal tumorsCIMP+
Smad3 rs893473CC/CT899491.00
TT60103.601.62–7.98
TGFβR1 rs10733710GG615271.00
GA/AA343322.101.24–3.57
KRAS2 mutation
Smad3 (rs991157)GG/GA8761501.00
AA83231.691.03–2.79
TP53 mutation
Smad3 rs11071933bCC3851271.00
CG/GG5721500.720.54–0.95
Smad3 rs750766GG304701.00
 Note: Similar results for rs12102171 and rs7176870GA/AA6532071.491.09–2.04
TGFβR1 rs10733710GG6151551.00
GA/AA3431051.401.06–1.84
  • aAdjusted for age, center, sex, and race.

  • btagSNPs presented for this gene are adjusted for one another.