Table 3.

Associations between variants in the TGF-β signaling pathway and NFκB1 and Smad2 and Smad3 and rectal cancer riska

Controls, nCases, nOR95% CIControls, nCases, nOR95% CIControls, nCases, nOR95% CI
 TGFβ1 rs1800469
GGGAAA
Smad3 rs2118610b
 GG1581191.001401040.990.70–1.4023351.951.09–3.48
 GA2241661.030.75–1.401781561.180.86–1.6352350.910.56–1.49
 AA83721.220.82–1.8176611.110.73–1.681940.290.10–0.88
Pinteraction0.01
Smad3 rs4147358c
 CC2542041.0022018110.76–1.3163310.580.36–0.93
 CA1841370.890.89–1.191381150.990.72–1.3526341.590.92–2.74
 AA27160.670.35–1.2836250.830.48–1.43591.960.64–6.03
Pinteraction<0.01
 TGFβ1 rs4803455
CCCAAA
NFκB1 rs13117745d
 CC2011301.003392741.250.95–1.651551321.350.98–1.86
 CT/TT52662.001.30–3.061421051.180.84–1.6569441.000.64–1.55
Pinteraction<0.01
 TGFβR1 rs10733710
GGGA/AA
NFκB1 rs4648110e
 TT4052701.002072011.451.13–1.86
 TA/AA2101841.331.04–1.72136981.080.80–1.47
Pinteraction<0.01
 TGFβR1 rs1571590
AAAGGG
Smad2 rs1792689
 CC4553791.002411830.910.72–1.1615282.421.27–4.61
 CT/TT1561120.840.63–1.1178480.750.51–1.111440.320.10–0.99
Pinteraction0.003
  • aAssociation adjusted for age, sex, race and center.

  • bSimilar associations were observed for SMAD3 rs991157 (G > A), Pinteraction < 0.01.

  • cSimilar associations were observed for SMAD3 rs745103 (T > A), Pinteraction < 0.01.

  • dSimilar associations were observed for NFκB1 rs4648110 (T > A), Pinteraction = 0.02.

  • dSimilar associations were observed for NFκB1 rs13117745 (C > T), Pinteraction = 0.01.