Table 2.

Interaction between variants in the TGF-β signaling pathway and NFκB1 and IKBκB and risk of colon cancera

Controls, nCases, nOR95% CIControls, nCases, nOR95% CIControls, nCases, nOR95% CI
 TGFβ1 rs1800469
GGGAAA
Smad3 rs3825977
 CC6105211.005424190.920.77 1.09116800.800.58 1.08
 CT2772300.990.80 1.232592010.900.72 1.1268350.570.37 0.88
 TT30431.671.03 2.7035190.640.36 1.141320.170.04 0.75
Pinteraction<0.01
 TGFβ1 rs4803455
CCCAAA
Smad2 rs4940086
 TT2321521.004653601.210.94–1.552071701.270.95–1.70
 TC2281621.100.83–1.474253351.240.96–1.591961801.461.09–1.95
 CC58260.710.43–1.181051131.711.22–2.3929502.721.64–4.49
Pinteraction0.02
Smad3 rs17293443
 TT/TC4853301.009477791.231.04–1.454203801.351.11–1.64
 CC33100.460.22–0.9448290.930.57–1.5111202.921.38–6.19
Pinteraction<0.01
Smad7 rs4939827
 TT1151061.002552250.990.72–1.371231100.990.69–1.44
 TC/CC4032330.630.46–0.867385820.870.65–1.163092901.040.76–1.42
Pinteraction0.02
 TGFβR1 rs6478974
CCCAAA
IKBκB rs3747811
 TT1481551.002552080.780.58–1.05124840.660.46–0.95
 TA2702190.780.58–1.044723520.720.55–0.952501710.670.49–0.90
 AA1151040.870.61–1.242391710.690.51–0.9483901.040.71–1.52
Pinteraction0.04
NFκB1 rs4648110
 TT3462891.006154740.930.76–1.142822331.010.80–1.28
 TA1631751.290.99–1.683112340.910.72–1.151561050.820.61–1.10
 AA24140.710.36–1.4040230.690.40–1.181970.470.20–1.15
Pinteraction0.04
 TGFβR1 rs1571590
AAAGGG
IKBκB rs3747811b
TT3472681.001661561.240.94–1.6214232.241.13–4.44
TA6405001.030.85–1.263172090.860.68–1.0935331.250.75–2.06
AA2732391.140.90–1.441471111.010.75–1.3617161.240.61–2.51
Pinteraction0.04
  • aAssociations adjusted for age, sex, center and race.

  • bSimilar associations were observed for NFκB1 rs13117745 (C > T), Pinteraction = 0.02.