Table 4.

Multivariate OR and 95% CI for breast cancer incidence by serum 25(OH)D3 concentration, nested case-control study in the E3N cohort (n = 1,908) stratified by age at blood collection <53 y (n = 618), 53 to 60 y (n = 653), and >60 y (n = 637)

Tertile of serum 25(OH)D3 (ng/mL)No. cases/no. controlsOR* (95% CI)OR (95% CI)OR (95% CI)OR§ (95% CI)
All636/1,272
<53 y
    <19.877/1251111
    19.8-2768/1400.78 (0.52-1.18)0.76 (0.49-1.16)0.77 (0.50-1.18)0.78 (0.50-1.20)
    >2750/1280.61 (0.39-0.97)0.60 (0.37-0.96)0.64 (0.40-1.03)0.60 (0.37-0.98)
    P trend0.040.030.070.04
53-60 y
    <19.876/1311111
    19.8-2770/1290.93 (0.62-1.41)0.95 (0.62-1.46)0.92 (0.60-1.41)0.85 (0.55-1.31)
    >2769/1560.77 (0.51-1.15)0.81 (0.53-1.23)0.77 (0.50-1.19)0.71 (0.46-1.10)
    P trend0.20.30.20.1
>60 y
    <19.873/1481111
    19.8-2760/1330.91 (0.60-1.39)0.94 (0.61-1.45)0.96 (0.62-1.49)0.94 (0.34-1.49)
    >2772/1281.11 (0.74-1.67)1.15 (0.75-1.77)1.15 (0.75-1.78)1.09 (0.70-1.71)
    P trend0.30.50.50.6
  • *ORs and CIs from unconditional logistic regression adjusted for age at blood collection, menopausal status (premenopausal or postmenopausal), age at menopause, mean daily UV dose exposure among the 40 centers of blood collection, and season of blood collection (same year).

  • From unconditional logistic regression adjusted for the same variables as in * plus BMI at the time of the blood collection, physical activity, age of menarche, number of children, tobacco status, previous use of oral contraceptives, MHT use (among postmenopausal women only), personal history of mammography, benign breast diseases, and previous family history of breast cancer.

  • From unconditional logistic regression adjusted for the same variables as in †, plus alcohol consumption, total energy intake without alcohol, calcium and dietary vitamin D assessed from the dietary questionnaire, and supplement intakes.

  • §From unconditional logistic regression adjusted for the same variables as in ‡ plus serum calcium, PTH, estradiol, and progesterone concentrations.

  • A separate fourth category for missing values (cases, n = 21; controls, n = 54) was considered; ORs were not significant.