Table 2.

Multivariate OR and 95% CI for breast cancer incidence by serum 25(OH)D3 concentration, nested case-control study in the E3N cohort (n = 1,908)

Tertile of serum 25(OH)D3 (ng/mL)No. cases/no. controlsOR* (95% CI)OR (95% CI)OR (95% CI)OR§ (95% CI)
All636/1,272
    <19.8226/4041111
    19.8-27198/4020.87 (0.68-1.10)0.84 (0.66-1.08)0.84 (0.66-1.08)0.81 (0.63-1.04)
    >27191/4120.80 (0.62-1.03)0.80 (0.62-1.04)0.81 (0.62-1.06)0.73 (0.55-0.96)
P trend0.090.100.120.02
  • *ORs and CIs from conditional logistic regression matched on age (±2 y), menopausal status (premenopausal or postmenopausal) at blood collection, age at menopause (±2 y), study center (same geographic localization in France among the 40 collection centers), and date of blood collection (same year).

  • Conditional logistic regression adjusted for the same variables as in * plus BMI at the time of blood collection, physical activity, age at menarche, number of children, tobacco status, previous use of oral contraceptives, MHT use (among postmenopausal women only), personal history of mammography, benign breast disease, and previous family history of breast cancer.

  • Conditional logistic regression adjusted for the same variables as in † plus alcohol consumption, total energy intake without alcohol, calcium and vitamin D dietary and supplement intakes assessed from the dietary questionnaire.

  • §Conditional logistic regression adjusted for the same variables as in ‡ plus serum calcium, PTH, estradiol, and progesterone concentrations.

  • A separate fourth category for missing values (cases, n = 21; controls, n = 54) was considered; OR were not significant.