Table 4.

Association between prognosis score and prostate cancer progression

No. of risk allelesProstate cancer progression patients, n (%)Nonprostate cancer progression patients, n (%)HR (95% CI)*P
≤143 (19.8)156 (29.3)1.00
266 (30.4)166 (31.1)1.55 (1.04-2.31)0.031
360 (27.7)130 (24.4)1.90 (1.26-2.88)0.002
4-748 (22.1)81 (15.2)2.19 (1.40-3.42)6.0 × 10−4
Per unit increase in risk alleles1.29 (1.12-1.47)3.0 × 10−4

NOTE: Prognosis score based on five risk alleles in ITGA6, NUDT10/NUDT11, KIAA1211, SLCC22A3, and HNF1B/TCF.

  • *Adjusted for age, genetic ancestry, institution, Gleason score, stage, treatment, and PSA at diagnosis.