Table 5.

Association between nevus phenotype and genotype and melanoma risk by age subgroup

Risk factorAge, <50 yAge, ≥50 y
ControlCaseOR (95% CI)PtrendControlCaseOR (95% CI)Ptrend
Residual log body nevus number quartile*
    Q145 (31%)26 (7%)81 (23%)29 (5%)
    Q230 (21%)55 (14%)3.08 (1.51-6.28)96 (27%)72 (13%)2.59 (1.46-4.59)
    Q334 (24%)91 (23%)4.48 (2.28-8.79)92 (26%)114 (21%)4.44 (2.54-7.74)
    Q435 (24%)224 (57%)10.27 (5.38-19.62)<0.000191 (25%)327 (60%)13.34 (7.76-22.94)<0.0001
Presence of atypical nevi*
    No125 (87%)250 (63%)337 (94%)407 (75%)
    Yes19 (13%)146 (37%)1.64 (0.90-3.01)0.1123 (6%)135 (25%)2.33 (1.39-3.91)0.001
rs12203592_chr6
    CC76 (55%)250 (65%)203 (58%)348 (65%)
    CT55 (40%)116 (30%)0.64 (0.43-0.97)130 (37%)163 (30%)0.73 (0.55-0.98)
    TT6 (4%)18 (5%)0.91 (0.35-2.38)0.1116 (5%)24 (4%)0.88 (0.45-1.69)0.08
rs7023329_chr9
    GG30 (22%)105 (29%)64 (19%)145 (29%)
    GA73 (54%)193 (52%)0.76 (0.46-1.23)201 (59%)248 (49%)0.55 (0.39-0.77)
    AA33 (24%)70 (19%)0.61 (0.34-1.08)0.0974 (22%)114 (22%)0.68 (0.45-1.03)0.06
rs2284063_chr22
    GG50 (36%)182 (48%)143 (41%)239 (46%)
    GA64 (46%)164 (43%)0.70 (0.46-1.08)162 (47%)232 (44%)0.86 (0.64-1.14)
    AA24 (17%)35 (9%)0.40 (0.22-0.74)0.00342 (12%)52 (10%)0.74 (0.47-1.17)0.15

NOTE: There was no statistically significant difference in melanoma risk between age groups for the nevus genotypes (P = 0.76, 0.75, and 0.12 for SNPs on chromosomes 6, 9, and 22, respectively).

  • *OR adjusted for age, sex, hair color, freckling as child, general skin type, and (for atypical nevi only) residual log body nevus number.

  • Crude ORs were reported.