Table 3.

Association between nevus phenotype and nevus genotype and risk of melanoma

Risk factorControlCaseUnivariate OR (95% CI)Multivariable OR1 (95% CI)*Adjusted OR2 (95% CI)
Residual log body nevus number quartile
Q1126 (25)55 (6)
Q2126 (25)127 (14)2.31 (1.55-3.45)1.98 (1.29-3.03)2.64 (1.71-4.08)
Q3126 (25)205 (22)3.73 (2.53-5.49)3.12 (2.07-4.70)4.32 (2.84-6.59)
Q4126 (25)551 (59)10.02 (6.91-14.52)7.47 (5.01-11.14)11.66 (7.78-17.48)
Atypical nevi
0462 (92)657 (70)
1+42 (8)281 (30)4.70 (3.33-6.64)2.80 (1.91-4.10)3.95 (2.75-5.66)
rs12203592_chr6
CC279 (57)598 (65)
CT185 (38)279 (30)0.70 (0.56-0.89)0.66 (0.51-0.86)0.67 (0.52-0.87)
TT22 (5)42 (5)0.89 (0.52-1.52)1.04 (0.57-1.91)0.80 (0.44-1.44)
Linear trend0.80 (0.66-0.96)0.83 (0.67-1.03)0.76 (0.61-0.94)
rs7023329_chr9
GG94 (20)250 (29)
GA274 (58)441 (50)0.61 (0.46-0.80)0.65 (0.48-0.88)0.58 (0.43-0.77)
AA107 (23)184 (21)0.65 (0.46-0.90)0.70 (0.48-1.01)0.63 (0.45-0.90)
Linear trend0.80 (0.68-0.95)0.85 (0.70-1.02)0.79 (0.67-0.94)
rs2284063_chr22
GG193 (40)421 (47)
GA226 (47)396 (44)0.80 (0.63-1.02)0.86 (0.66-1.13)0.82 (0.64-1.06)
AA66 (14)87 (10)0.60 (0.42-0.87)0.72 (0.48-1.09)0.61 (0.42-0.89)
Linear trend0.79 (0.67-0.93)0.86 (0.71-1.04)0.79 (0.67-0.94)
Total number of variants (T allele for rs12203592_chr6, and A allele for rs7023329_chr9 and rs2284063_chr22)
0/1122 (26)303 (35)
2154 (33)306 (36)0.80 (0.60-1.07)0.81 (0.59-1.11)0.75 (0.56-1.02)
3133 (29)186 (22)0.56 (0.42-0.77)0.67 (0.48-0.95)0.55 (0.40-0.76)
4+57 (12)60 (7)0.42 (0.28-0.64)0.58 (0.36-0.92)0.43 (0.28-0.67)
Linear trend0.77 (0.69-0.86)0.85 (0.75-0.95)0.77 (0.69-0.86)
  • *All risk factors listed in the table except for total number of variants were included in the multivariable model (multivariable OR1); age-sex–corrected log body nevus number and presence of atypical nevi were adjusted in OR1 for total number of variants.

  • Adjusted for age, sex, hair color, freckling as child, general skin type without other nevus phenotype or genotype.