Table 2.

Association between nevus genotype and total body nevus number, large normal nevus number, and presence of atypical nevi adjusted for case-control status

Nevus genotypeN (%)Total body nevus number*No. of large neviPresence of atypical nevi
Controls median (Q1, Q3)Cases median (Q1, Q3)β (95% CI)PtrendRate ratio (95% CI)PtrendRisk ratio (95% CI)Ptrend
rs12203592_chr6
    CC872 (62%)16 (8, 29)41 (21, 77)
    CT463 (33%)15 (6, 30)44 (21, 94)0.04 (−0.07 to 0.15)0.88 (0.73-1.06)0.86 (0.69-1.06)
    TT64 (5%)14 (8, 24)33 (14, 62)−0.27 (−0.51 to −0.03)0.430.52 (0.33-0.83)0.010.67 (0.38-1.18)0.05
rs7023329_chr9
    GG343 (26%)17 (8, 32)43 (21, 93)
    GA713 (53%)15 (7, 29)41 (20, 78)−0.15 (−0.28 to −0.02)0.79 (0.64-0.98)0.82 (0.66-1.03)
    AA289 (21%)15 (7, 24)41 (20, 77)−0.15 (−0.30 to −0.00)0.040.77 (0.59-0.99)0.030.94 (0.71-1.23)0.54
rs2284063_chr22
    GG611 (44%)17 (8, 35)45 (21, 89)
    GA620 (45%)15 (7, 27)40 (20, 77)−0.12 (−0.23 to −0.02)0.75 (0.62-0.90)0.99 (0.81-1.21)
    AA152 (11%)13 (6, 28)39 (20, 77)−0.24 (−0.41 to −0.07)0.0020.73 (0.54- 0.98)0.0021.05 (0.76-1.46)0.87
  • *Median total body nevus number (first quartile, third quartile) for controls and cases are presented separately, but subsequent analyses are for the total sample adjusted for case-control status; age-sex–corrected log-transformed body nevus number was used to test for association, and linear regression coefficient (β) and its 95% CIs are presented.

  • Analyses were carried out using Negative Binomial regression models and rate ratios are presented.

  • Modified Poisson regression models with robust error variance were used to analyze presence of atypical nevi, and risk ratios are presented.