Table 1.

ORs and 95% CIs for risk of prostate cancer associated with meat preference, NAT1, and NAT2 genotype

TotalAfrican AmericanJapanese AmericanLatinoCaucasian
Cases/controlsOR (95% CI), adjusted for age and ethnicity*OR (95% CI), multivariate adjustedCases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)
Meat preference
Rare/no meat184/1601.001.0022/151.0038/401.0039/291.0075/691.00
Medium902/8920.86 (0.68-1.09)0.93 (0.76-1.14)173/1690.68 (0.34-1.36)269/2521.01 (0.62-1.65)191/2090.67 (0.40-1.13)230/2290.94 (0.64-1.37)
Well-done1,020/1,0110.85 (0.67-1.08)0.84 (0.66-1.07)404/3870.73 (0.37-1.43)117/1280.87 (0.51-1.47)366/3500.72 (0.44-1.21)116/1230.84 (0.55-1.27)
P for trend§0.300.230.940.410.690.38
Genotypes
NAT1*10
    0 copies864/8411.001.00200/1871.00145/1181.00229/2451.00282/2811.00
    1 copy878/8730.98 (0.86-1.13)0.98 (0.86-1.13)278/2651.00 (0.77-1.30)179/2040.72 (0.53-1.00)262/2571.09 (0.85-1.39)125/1211.04 (0.77-1.40)
    2 copies364/3491.01 (0.84-1.21)1.01 (0.84-1.22)121/1190.96 (0.70-1.33)100/980.84 (0.58-1.21)105/861.30 (0.92-1.82)14/190.73 (0.36-1.49)
    P for trend§0.990.960.830.270.140.73
NAT2
    Rapid379/3551.001.0065/481.00202/2041.0068/651.0027/211.00
    Intermediate909/8940.93 (0.78-1.12)0.92 (0.77-1.11)254/2750.68 (0.45-1.02)169/1750.97 (0.73-1.29)284/2681.02 (0.70-1.48)167/1470.88 90.48-1.62)
    Slow818/8140.91 (0.75-1.11)0.91 (0.75-1.11)280/2480.82 (0.55-1.24)53/411.28 (0.81-2.01)244/2550.92 (0.63-1.35)227/2530.70 (0.38-1.27)
    P for trend§0.420.420.870.490.500.07
Intermediate/rapid1,288/1,2491.001.00319/3231.00371/3791.00352/3331.00194/1681.00
    Slow818/8140.97 (0.85-1.10)0.97 (0.95-1.11)280/2481.14 (0.90-1.43)53/411.29 (0.84-1.99)244/2550.91 (0.72-1.15)227/2530.78 (0.60-1.03)
  • *Adjusted for age groups and ethnicity as strata in a conditional logistic regression model.

  • Adjusted for age groups and ethnicity as strata in a conditional logistic regression model, and for energy, body mass index, years of education, family history of prostate cancer, and smoking status (never/former/current) as covariates.

  • Adjusted for age groups as strata in a conditional logistic regression model.

  • §Wald statistic for trend variables assigned the number of variant alleles for NAT1 (zero, one, and two copies, respectively) and NAT2 (slow, intermediate, and rapid, respectively).