Table 1.

TERT SNP genotype and mean telomere length

TERT rs401681δΔCt (95% CI)
Breast cancer (6,434 controls)Melanoma (979 controls)SIBS (1,655 controls)Colorectal cancer (2,246 controls)Combined (11,314 controls)
CC0.00 reference0.00 reference0.00 reference0.00 reference0.00 reference
CT−0.002 (−0.02 to 0.02)0.06 (0.003-0.1)−0.002 (−0.04 to 0.04)0.01 (−0.02 to 0.05)0.02 (−0.005 to 0.04)
TT−0.02 (−0.03 to 0.02)0.03 (−0.05 to 0.1)0.03 (−0.02 to 0.08)0.004 (−0.04 to 0.05)0.04 (−0.03 to 0.04)
Per T alleleP trend = 0.86P trend = 0.38P trend = 0.29P trend = 0.78P trend = 0.61

NOTE: Genotype frequencies and mean telomere length, as represented by the continuous ΔCt variable, were analyzed in control samples using linear regression for the “per T allele” change in mean telomere length (δΔCt), with associated 95% CI. Analyses were adjusted for 384-well plate and age in all the studies, and for gender and family where applicable.