Table 2.

Association between ovarian cancer risk factors and anti-MUC1 antibodies among 339 controls from the Nurses' Health Studies

N (%)Geometric mean*P
Anti-MUC1 antibody0.57
Age at blood draw (quartiles), y
    <5173 (22)0.60
    51-5698 (29)0.60
    57-6386 (25)0.61
    64+82 (24)0.480.03
BMI, kg/m2
    <30195 (58)0.59
    30+143 (42)0.550.23
Height, inches
    <65162 (48)0.58
    65+177 (52)0.570.87
Age at menarche, y
    <13151 (45)0.58
    13+188 (55)0.570.93
Use of oral contraceptive
    Never183 (54)0.55
    Ever156 (46)0.610.13
Tubal ligation
    No271 (80)0.55
    Yes68 (20)0.660.03
Ever used Intrauterine Device
    No317 (94)0.58
    Yes22 (6)0.540.62
Hysterectomy
    No267 (79)0.57
    Yes72 (21)0.590.67
Age at first birth (tertiles), y
    <2388 (27)0.59
    23-2494 (29)0.56
    25+143 (44)0.560.49
Number of live births
    014 (4)0.66
    1 or 2105 (31)0.54
    3 or 4165 (49)0.59
    5+55 (16)0.590.70
Breastfeeding
    Never105 (33)0.54
    Ever218 (67)0.590.16
Age at menopause, y
    <5161 (30)0.62
    51+144 (70)0.530.10
Current Post-menopausal hormone use§
    No113 (55)0.55
    Yes93 (45)0.560.80
No. of ovulatory months (quartiles)§
    <33971 (24)0.63
    339-38973 (25)0.61
    390-42673 (25)0.55
    427+73 (25)0.510.04
Bone fractures/osteoporosis
    No285 (89)0.56
    Yes36 (11)0.600.58
Talc use (in 1982)
    Less than weekly250 (78)0.59
    At least weekly71 (22)0.510.09
  • *Adjusted for age at blood collection in years (continuous) and by assay plate (indicators).

  • P-trend from linear regression modeling categorical variables linearly, adjusting for age (continuous) and assay plate (indicators).

  • Among parous women.

  • §Among women with known menopause status.

  • Available in NHS only.