Table 4.

Relative risks of incident breast cancer for continuous z-scores with 95% CIs obtained in Cox regression analyses, stratified by attained age and BMI at measurement

ExposureRR (95% CI)*RR (95% CI)RR (95% CI)*RR (95% CI)RR (95% CI)*RR (95% CI)
Attained age <50 yAttained age 50-59 yAttained age ≥60 y
Three lowest BMI quintiles (combined)
    Blood pressure1.03 (0.90-1.19)0.99 (0.85-1.16)1.12 (0.97-1.30)1.14 (0.97-1.33)0.95 (0.84-1.08)0.92 (0.81-1.05)
    Glucose1.38 (1.08-1.75)1.51 (1.16-1.96)0.88 (0.66-1.17)0.92 (0.67-1.26)1.15 (0.90-1.46)1.19 (0.92-1.54)
    Cholesterol0.94 (0.84-1.06)0.95 (0.83-1.08)0.97 (0.86-1.09)1.01 (0.88-1.16)0.88 (0.79-0.98)0.89 (0.79-1.00)
    Triglycerides0.92 (0.80-1.07)0.86 (0.73-1.02)0.91 (0.77-1.07)0.90 (0.75-1.09)1.01 (0.87-1.17)1.05 (0.88-1.25)
    MetS1.02 (0.89-1.16)0.95 (0.82-1.11)0.96 (0.84-1.09)
Two highest BMI quintiles (combined)
    Blood pressure0.79 (0.65-0.95)0.82 (0.66-1.02)0.94 (0.79-1.12)0.96 (0.80-1.14)1.04 (0.94-1.16)1.01 (0.90-1.12)
    Glucose0.86 (0.60-1.24)0.91 (0.62-1.34)1.11 (0.81-1.52)1.14 (0.83-1.58)1.16 (0.97-1.40)1.11 (0.92-1.34)
    Cholesterol0.78 (0.67-0.90)0.87 (0.72-1.04)0.91 (0.79-1.05)0.93 (0.79-1.09)0.86 (0.78-0.94)0.85 (0.77-0.94)
    Triglycerides0.74 (0.61-0.89)0.83 (0.66-1.04)0.97 (0.82-1.16)0.97 (0.79-1.20)1.02 (0.90-1.15)1.06 (0.92-1.22)
    MetS0.67 (0.57-0.78)0.96 (0.83-1.12)1.03 (0.93-1.13)
  • *Stratified for cohort and adjusted for year of birth, smoking and quintile levels of BMI (except MetS). RRs are corrected for RDR; conversion into uncorrected RR = exp[log(RR)*RDR]. RDR: BMI, 0.90; systolic BP, 0.54; diastolic BP, 0.51; glucose, 0.27; cholesterol, 0.66; triglycerides, 0.50.

  • Stratified for cohort and adjusted for year of birth, smoking, quintile levels of BMI, and the other individual z-scores. z-scores, derived from original values, were calibrated.

  • Standardized sum of the z-scores for BMI, blood pressure, glucose, cholesterol, and triglycerides.