Table 3.

Relative risks of breast cancer incidence and mortality for continuous z-scores with 95% CIs obtained in Cox regression analyses, stratified by attained age

ExposureRR (95% CI)*RR (95% CI)RR (95% CI)*RR (95% CI)RR (95% CI)*RR (95% CI)
Attained age <50 yAttained age 50-59 yAttained age ≥60 y
Breast cancer incidence
    BMI0.86 (0.80-0.92)0.87 (0.80-0.95)0.96 (0.90-1.02)0.96 (0.88-1.05)1.07 (1.02-1.13)1.03 (0.97-1.10)
    Blood pressure0.89 (0.80-0.99)0.94 (0.83-1.07)1.02 (0.92-1.13)1.06 (0.94-1.19)1.03 (0.95-1.11)0.97 (0.89-1.05)
    Glucose1.13 (0.93-1.38)1.30 (1.05-1.61)0.96 (0.78-1.19)1.03 (0.82-1.30)1.20 (1.04-1.38)1.16 (0.99-1.36)
    Cholesterol0.86 (0.79-0.94)0.92 (0.83-1.02)0.94 (0.85-1.03)0.98 (0.88-1.08)0.87 (0.81-0.93)0.87 (0.80-0.93)
    Triglycerides0.80 (0.72-0.90)0.85 (0.74-0.97)0.93 (0.83-1.04)0.94 (0.81-1.08)1.05 (0.96-1.15)1.06 (0.95-1.18)
    MetS0.83 (0.76-0.90)0.95 (0.87-1.04)1.04 (0.97-1.12)
Breast cancer mortality
    BMI1.06 (0.86-1.32)0.88 (0.66-1.17)1.05 (0.89-1.25)0.99 (0.79-1.23)1.00 (0.89-1.14)0.87 (0.75-1.02)
    Blood pressure1.35 (0.94-1.93)1.22 (0.78-1.89)1.17 (0.89-1.54)1.12 (0.82-1.52)1.29 (1.07-1.56)1.24 (1.02-1.52)
    Glucose1.47 (0.74-2.92)1.26 (0.59-2.70)1.14 (0.66-1.96)1.24 (0.70-2.22)1.57 (1.13-2.18)1.50 (1.05-2.14)
    Cholesterol0.80 (0.58-1.10)0.63 (0.42-0.92)0.94 (0.74-1.20)0.96 (0.73-1.27)1.00 (0.84-1.18)0.97 (0.81-1.17)
    Triglycerides1.38 (0.95-2.01)1.58 (0.99-2.54)0.97 (0.71-1.32)0.90 (0.62-1.31)1.14 (0.91-1.42)1.00 (0.76-1.31)
    MetS1.21 (0.91-1.62)1.07 (0.84-1.35)1.23 (1.04-1.45)
  • *Stratified for cohort and adjusted for year of birth, age at measurement, and smoking. RRs are corrected for RDR; conversion into uncorrected RR = exp[log(RR)*RDR]. RDR: BMI, 0.90; systolic BP, 0.54; diastolic BP, 0.51; glucose, 0.27; cholesterol, 0.66; triglycerides, 0.50.

  • Stratified for cohort and adjusted for year of birth, smoking, and the other individual z-scores. z-scores, derived from original values, were calibrated.

  • Standardized sum of the z-scores for BMI, blood pressure, glucose, cholesterol, and triglycerides.