Table 2.

Relative risks of incident breast cancer with 95% CIs obtained in Cox regression analyses

ExposureCohort-specific quintilesMean (SD)Total no. of casesRR (95% CI)*Attained age (y)
<5050-59≥60
RR (95% CI)*RR (95% CI)*RR (95% CI)*
BMI120.0 (1.2)8331.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
222.3 (0.8)9391.01 (0.91-1.12)1.04 (0.89-1.23)0.94 (0.78-1.15)1.01 (0.84-1.22)
324.1 (0.8)9760.95 (0.86-1.06)0.92 (0.78-1.10)0.91 (0.75-1.11)1.01 (0.84-1.21)
426.4 (1.0)1,0490.96 (0.86-1.06)0.90 (0.75-1.08)0.89 (0.73-1.09)1.04 (0.87-1.25)
531.7 (3.6)1,0650.98 (0.88-1.09)0.70 (0.57-0.85)0.87 (0.71-1.07)1.21 (1.01-1.43)
Ptrend0.7<0.0010.20.003
Systolic BP1104.5 (5.9)7611.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
2114.4 (3.3)7480.99 (0.82-1.19)0.84 (0.63-1.12)1.02 (0.72-1.45)1.24 (0.86-1.77)
3122.7 (3.0)9670.96 (0.80-1.14)1.11 (0.84-1.47)0.82 (0.59-1.15)0.98 (0.71-1.36)
4133.6 (4.8)1,1421.00 (0.84-1.20)0.97 (0.71-1.31)1.07 (0.76-1.49)1.05 (0.76-1.43)
5156.3 (16.1)1,2280.96 (0.79-1.15)0.84 (0.59-1.20)1.03 (0.72-1.47)1.08 (0.79-1.47)
Ptrend0.80.50.60.8
Diastolic BP163.5 (5.5)8141.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
270.3 (3.5)6971.02 (0.84-1.25)0.86 (0.63-1.18)0.86 (0.58-1.25)1.37 (0.96-1.95)
376.9 (3.6)1,2031.08 (0.91-1.29)1.08 (0.81-1.44)0.97 (0.70-1.36)1.21 (0.89-1.65)
481.0 (3.5)9051.06 (0.87-1.28)1.17 (0.85-1.60)0.95 (0.66-1.37)1.10 (0.79-1.54)
592.6 (7.6)1,2271.02 (0.84-1.22)0.68 (0.48-0.97)1.02 (0.72-1.44)1.22 (0.90-1.66)
Ptrend1.00.20.70.6
Glucose14.1 (0.5)8781.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
24.6 (0.3)8871.01 (0.71-1.43)0.97 (0.53-1.75)0.74 (0.39-1.42)1.32 (0.75-2.33)
35.0 (0.3)1,0051.07 (0.76-1.50)1.23 (0.69-2.20)0.87 (0.47-1.63)1.15 (0.67-1.99)
45.4 (0.3)1,0411.44 (1.03-2.01)1.40 (0.78-2.52)0.95 (0.50-1.79)1.97 (1.15-3.35)
56.6 (1.7)1,0421.30 (0.93-1.83)1.28 (0.69-2.38)0.98 (0.51-1.88)1.61 (0.95-2.72)
Ptrend0.080.30.90.09
Cholesterol14.2 (0.4)8231.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
24.9 (0.2)9050.97 (0.84-1.13)1.06 (0.85-1.32)0.99 (0.76-1.30)0.80 (0.61-1.05)
35.5 (0.3)9900.95 (0.82-1.09)0.86 (0.68-1.09)1.13 (0.87-1.48)0.81 (0.63-1.04)
46.1 (0.3)1,0460.87 (0.76-1.01)0.93 (0.73-1.19)0.84 (0.63-1.11)0.78 (0.61-1.00)
57.3 (0.9)1,0770.74 (0.64-0.86)0.67 (0.50-0.89)0.93 (0.70-1.24)0.64 (0.50-0.81)
Ptrend<0.0010.0020.4<0.001
Triglycerides10.6 (0.1)8841.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
20.9 (0.1)9161.10 (0.91-1.32)1.02 (0.75-1.37)1.01 (0.71-1.42)1.36 (0.98-1.89)
31.1 (0.1)9190.92 (0.76-1.10)0.96 (0.70-1.30)0.91 (0.64-1.29)1.02 (0.74-1.41)
41.5 (0.2)9600.89 (0.73-1.07)0.87 (0.63-1.21)0.87 (0.61-1.25)1.07 (0.78-1.47)
52.5 (1.1)1,0440.92 (0.76-1.11)0.65 (0.45-0.93)0.91 (0.63-1.31)1.26 (0.92-1.73)
Ptrend0.10.0020.60.3
  • *Stratified for cohort and adjusted for year of birth, age at measurement, smoking, and quintile levels of BMI (except BMI). RRs are corrected for RDR; conversion into uncorrected RR = exp[log(RR)*RDR]. RDR: BMI, 0.90; systolic BP, 0.54; diastolic BP, 0.51; glucose, 0.27; cholesterol, 0.66; triglycerides, 0.50.