Table 4.

Geometric mean and 95% CI for breast density at follow-up in DISC intervention and usual care groups

Intervention groupUsual care groupP*
nMean (5-95% CI)nMean (5-95% CI)
Percent dense tissue (%)
    Unadjusted8721.2 (17.1-26.3)9516.7 (13.6-20.5)0.12
    Adjusted (excluding current diet)8420.2 (17.5-23.3)9218.3 (16.0-21.0)0.35
    Adjusted (including current diet)8219.7 (17.0-22.7)8918.3 (15.9-21.0)0.51
Volume of dense tissue (mm3)
    Unadjusted (mm3)8786,046 (70,990-104,296)9573,338 (60,801-88,460)0.20
    Adjusted (excluding current diet)8483,307 (70,138-98,947)9274,788 (63,351-88,289)0.34
    Adjusted (including current diet)8279,460 (67,882-93,012)8975,382 (64,848-87,626)0.65
  • *P values from Wald test using linear mixed-effects regression.

  • Adjusted for % body fat from DXA, BMI at baseline (Z-score), age at visit, age at randomization, race, smoking status, education, leisure physical activity at 14 to 17 y old and during the past year, duration of hormonal contraceptive use, and number of full-term pregnancies.

  • Adjusted for % body fat from DXA, BMI at baseline (Z-score), age at visit, age at randomization, race, smoking status, education, leisure physical activity at 14 to 17 y old and during the past year, duration of hormonal contraceptive use, number of full-term pregnancies, current intake of energy (kcal), % saturated fat, % monounsaturated fat, % polyunsaturated fat, cholesterol (mg/1,000 kcal), insoluble fiber (g/1,000 kcal), and soluble fiber (g/1,000 kcal).