Table 3.

Geometric mean and 95% CI for serum hormone concentrations at follow-up in DISC intervention and usual care groups

Intervention groupUsual care groupP*
nMean (5-95% CI)nMean (5-95% CI)
Progesterone (ng/mL)
    Unadjusted473.7 (2.3-6.1)404.9 (2.9-8.4)0.47
    Adjusted (excluding current diet)464.8 (3.2-7.2)394.4 (2.8-6.8)0.79
    Adjusted (including current diet)454.7 (3.1-7.1)363.9 (2.4-6.2)0.57
Total estradiol (pg/mL)
    Unadjusted47120.4 (90.1-160.8)40115.6 (84.9-157.3)0.84
    Adjusted (excluding current diet)46131.3 (101.8-169.4)39114.6 (87.4-150.4)0.40
    Adjusted (including current diet)45141.5 (116.1-172.4)3696.7 (77.1-121.2)0.02
Non–SHBG-bound estradiol (pg/mL)
    Unadjusted4687.9 (71.8-107.5)4080.8 (65.4-99.8)0.55
    Adjusted (excluding current diet)4593.2 (79.2-109.7)3978.6 (66.0-93.7)0.18
    Adjusted (including current diet)4497.6 (84.1-113.2)3667.1 (56.7-79.4)0.003
SHBG (nmol/L)
    Unadjusted4650.3 (42.6-59.4)4050.0 (41.8-59.8)0.97
    Adjusted (excluding current diet)4552.8 (46.0-60.5)3947.1 (40.7-54.6)0.29
    Adjusted (including current diet)4451.7 (44.9-59.4)3648.1 (41.0-56.4)0.55
  • *P values from Wald test using linear mixed-effects regression.

  • Adjusted for BMI at visit, BMI at baseline (Z-score), age at visit, age at randomization, race, smoking status, education, leisure physical activity at 14 to 17 y old and during the past year, days until next menses (cubic spline), duration of hormonal contraceptive use, and number of full-term pregnancies.

  • Adjusted for BMI at visit, BMI at baseline (Z-score), age at visit, age at randomization, race, smoking status, education, leisure physical activity at 14 to 17 y old and during the past year, days until next menses (cubic spline), duration of hormonal contraceptive use, number of full-term pregnancies, current dietary intake of energy (kcal), % saturated fat, % monounsaturated fat, % polyunsaturated fat, cholesterol (mg/1,000 kcal), insoluble fiber (g/1,000 kcal), and soluble fiber (g/1,000 kcal).