Table 6.

Multivariate HR and 95% CI according to dietary intakes at ages 12 to 13 years and glioma risk

IntakeQuintile of intakeP for trendP for sex interaction
Q1Q2Q3Q4Q5
Processed meat
    Median intake*5.413.521.130.245.5
    No. of cases5955499164
    Multivariate HR1.000.910.801.410.970.450.54
    95% CI(Reference)0.63–1.320.54–1.171.00–1.990.66–1.40
Nitrite plus nitrate, processed meat sources
    Median intake0.370.991.702.513.94
    No. of cases5559498669
    Multivariate HR1.001.050.861.471.160.160.44
    95% CI(Reference)0.72–1.520.58–1.281.03–2.080.80–1.67
Red meat
    Median intake*22.139.051.564.785.7
    No. of cases6154627269
    Multivariate HR 1.000.860.981.131.080.330.55
    95% CI(Reference)0.60–1.250.68–1.400.79–1.600.76–1.54
Dietary vitamin C
    Median intake1725365484
    No. of cases6366685863
    Multivariate HR1.001.041.070.931.030.930.63
    95% CI(Reference)0.73–1.470.76–1.510.65–1.330.72–1.47
Joint intake§
Nitrite plus nitrate/dietary vitamin CLow/highLow/lowHigh/highHigh/lowP for joint interaction
Nitrite plus nitrate, processed meat sources, median intake0.840.842.772.77
Dietary vitamin C, median intake59235923
    No. of cases726777102
    Multivariate HR1.001.011.121.320.50
    95% CI(Reference)0.73–1.420.81–1.560.97–1.81
  • *g/1,000 kcal/d (where kcal is based on energy intake at ages 12–13 years).

  • Adjusted for sex, age (continuous), race (non-Hispanic white, non-Hispanic black, other, and missing), energy intake at baseline (continuous), education (<high school, high school graduate, post–high school other than college, some college, college graduate, postgraduate, and missing), height (eight prespecified categories and missing), history of cancer at baseline (yes, no, and missing), energy intake at ages 12 to 13 years (continuous), BMI at age 18 years (five prespecified categories and missing), and physical activity at ages 15 to 18 years (quintiles of metabolic equivalent hours per week and missing).

  • mg/1,000 kcal/d (where kcal is based on energy intake at ages 12–13 years).

  • §Low/high distinctions were based on median intake values.