Table 4.

Multivariate HR and 95% CI according to category of vitamin C and vitamin E intake and glioma risk

Vitamin intakeCategory of intakeP for trendP for sex interaction
Vitamin C, dietaryQ1Q2Q3Q4Q5
    Median intake*355980107160
    No. of cases98113143116115
    Multivariate HR1.001.151.471.221.260.190.89
    95% CI(Reference)0.87–1.501.14–1.910.93–1.610.96–1.66
Vitamin C, supplemental0>0–99100–499500–999≥1,000
    Median intake0602035601,060
    No. of cases18910410610581
    Multivariate HR1.000.931.401.341.090.190.15
    95% CI(Reference)0.73–1.191.10–1.781.06–1.700.84–1.41
Vitamin E, dietaryQ1Q2Q3Q4Q5
    Median intake§6.27.68.69.812.1
    No. of cases108109122127119
    Multivariate HR1.001.011.151.231.170.120.042
    95% CI(Reference)0.77–1.310.89–1.490.95–1.590.90–1.53
    Vitamin E, dietary (males)
        No. of cases8489869565
        Multivariate HR1.001.131.171.411.040.50
        95% CI(Reference)0.84–1.520.87–1.581.05–1.890.75–1.44
    Vitamin E, dietary (females)
        No. of cases2420363254
        Multivariate HR1.000.661.040.831.280.072
        95% CI(Reference)0.36–1.190.62–1.740.49–1.400.79–2.07
Vitamin E, supplemental0>0–99100–399400–799≥800
    Median intake030221430830
    No. of cases1951695713331
    Multivariate HR1.001.091.051.271.020.270.42
    95% CI(Reference)0.89–1.340.78–1.411.02–1.580.70–1.49
  • *mg/1,000 kcal/d.

  • Adjusted for sex, age (continuous), race (non-Hispanic white, non-Hispanic black, other, and missing), energy intake (continuous), education (<high school, high school graduate, post–high school other than college, some college, college graduate, postgraduate, and missing), height (eight prespecified categories and missing), and history of cancer at baseline (yes, no, and missing).

  • mg/d.

  • §IU/1,000 kcal/d.

  • IU/d.