Table 4.

HRs and 95% CIs of subsite-specific colon cancer according to absolute weight change

Weight change (kg)Ptrend*
≤−2−1.9 to 1.92.0-4.95.0-9.9≥10.0
Men (n = 21,687)
Person-years61,577118,217102,65574,93423,334
Total colon
No. cases4590784723
Age-adjusted HR (95% CI)0.97 (0.68-1.38)1 (reference)1.06 (0.79-1.44)0.94 (0.66-1.34)1.62 (1.02-2.56)0.25
Multivariable HR (95% CI)0.87 (0.60-1.25)1 (reference)1.06 (0.78-1.43)0.92 (0.64-1.31)1.45 (0.91-2.31)0.52
Proximal colon
No. cases194547228
Age-adjusted HR (95% CI)0.82 (0.48-1.41)1 (reference)1.28 (0.85-1.92)0.88 (0.53-1.47)1.13 (0.53-2.39)0.67
Multivariable HR (95% CI)0.76 (0.44-1.31)1 (reference)1.26 (0.84-1.90)0.86 (0.51-1.44)1.02 (0.47-2.18)0.45
Distal colon
No. cases2133242311
Age-adjusted HR (95% CI)1.23 (0.71-2.12)1 (reference)0.90 (0.53-1.52)1.27 (0.75-2.17)2.12 (1.07-4.22)0.06
Multivariable HR (95% CI)1.07 (0.61-1.86)1 (reference)0.89 (0.53-1.51)1.22 (0.71-2.08)1.87 (0.93-3.75)0.14
Women (n = 21,539)
Person-years64,460109,029102,66985,11233,952
Total colon
No. cases5779555227
Age-adjusted HR (95% CI)1.19 (0.84-1.67)1 (reference)0.77 (0.55-1.09)0.93 (0.66-1.33)1.28 (0.82-1.98)0.46
Multivariable HR (95% CI)1.05 (0.74-1.50)1 (reference)0.79 (0.56-1.11)0.94 (0.66-1.34)1.20 (0.77-1.88)0.50
Proximal colon
No. cases3644342618
    Age-adjusted HR (95% CI)1.34 (0.87-2.09)1 (reference)0.86 (0.55-1.34)0.84 (0.52-1.36)1.53 (0.88-2.65)0.38
    Multivariable HR (95% CI)1.21 (0.77-1.90)1 (reference)0.88 (0.56-1.38)0.85 (0.52-1.38)1.46 (0.83-2.56)0.45
Distal colon
No. cases183318229
Age-adjusted HR (95% CI)0.90 (0.51-1.60)1 (reference)0.61 (0.34-1.08)0.95 (0.55-1.63)1.02 (0.49-2.14)0.85
Multivariable HR (95% CI)0.76 (0.42-1.37)1 (reference)0.61 (0.34-1.09)0.94 (0.54-1.62)0.91 (0.43-1.94)0.97
  • *To test for linear trend, weight change was modeled as a continuous variable. The test was restricted to subjects who gained or maintained weight.

  • Age-adjusted HRs based on a stratified Cox model (year of birth: <1930, 1930-1934, 1935-1939, 1940-1944, ≥1945) using attained age as the time variable.

  • Multivariable HRs are based on the age-adjusted model, additionally adjusted for baseline BMI, level of physical activity, height, energy intake, smoking, education, and county of residence.