Table 2.

Estimated percent changes and 95% CIs in DNA adducts in lung and blood MNC per 1010 nucleotides by GSTs polymorphisms and NAT2 activity

DNA adduct in lungDNA adduct in blood MNC
n (%)Adjusted GM (95% CI)*%Change (95% CI)n (%)Adjusted GM (95% CI)*%Change (95% CI)
GSTM1
    Null56 (43.8)173.9 (100.9-299.7)150.3 (35.4-362.6)24 (46.1)88.2 (33.5-231.9)267.4 (28.2-952.9)
    Wild-type72 (56.2)69.5 (41.1-117.3)Reference28 (53.9)24.0 (8.9-64.4)Reference
GSTP1
    AG or GG57 (48.3)115.1 (65.9-201.0)9.7 (−40.7 to 103.0)27 (54.0)67.5 (22.5-202.7)115.4 (−30.1 to 564.1)
    AA62 (51.7)104.9 (63.0-174.8)Reference23 (46.0)31.3 (12.9-76.1)Reference
GSTT1
    Null17 (14.0)119.7 (53.0-270.5)18.6 (−50.5 to 184.0)5 (9.4)57.2 (12.1-269.8)54.6 (−68.2 to 652.1)
    Wild-type104 (86.0)100.9 (73.0-139.5)Reference48 (90.6)37.0 (21.8-62.7)Reference
NAT2 activity
    Slow48 (58.5)144.9 (87.1-241.2)73.9 (−3.2 to 212.4)23 (67.7)39.0 (16.6-91.8)−28.2 (−70.5 to 74.8)
    Rapid34 (41.5)83.3 (48.5-143.2)Reference11 (32.3)54.3 (20.0-147.4)Reference

NOTE: Coefficients are expressed as percent changes in aromatic DNA adduct–associated GST polymorphisms and NAT2 activity adjusted for age at diagnosis, sex, smoking status, pack-years, and GSTM1, GSTT1, GSTP1, and NAT2 genes.

Abbreviation: GM, geometric mean.

  • *Adjusted for age at diagnosis, sex, smoking status, pack-years, and GSTM1, GSTT1, GSTP1, and NAT2 genes.

  • P < 0.05.

  • P < 0.1.