Table 2.

Characteristics of CIN3 by hierarchically defined HPV risk group: HPV16 > other carcinogenic HPV genotypes (Carc. excl. HPV16) > noncarcinogenic HPV > PCR negative

Characteristics at diagnosisn (%)HPV16Carc. (excl. HPV16)NoncarcinogenicPCR negativeP
n = 364n = 216n = 21n = 7
Median age (y)608 (100)23.52524400.0003
n (%)Row %Row %Row %Row %
Second diagnosis
    <CIN242 (7)3648107<0.0005
    CIN2236 (39)534241
    CIN3330 (54)682920
Smoking status
    Never247 (41)5541320.005
    Former80 (13)543944
    Current281 (46)663040
Oral contraceptive use
    Never156 (26)5640310.04
    Former127 (21)583460
    Current273 (45)663220
    Missing52 (9)444660
Parity
    Never pregnant162 (27)6729400.03
    0 births76 (13)663310
    1 birth159 (26)603731
    ≥2 births211 (35)524053
Worst cytologic interpretation
    Negative45 (7)4042117<0.0005
    ASCUS70 (12)543664
    LSIL107 (18)633521
    HSIL/ASC-H385 (63)633530
Study arm
    Immediate colposcopy227 (37)5735620.1
    HPV triage163 (27)603821
    Conservative management218 (36)633421

Abbreviations: HSIL, high-grade squamous intraepithelial lesion; ASC-H, atypical squamous cells, cannot rule out HSIL.