Table 2.

ORs for prostate cancer by categorical (quartiles) and continuous (loge-transformed) measures of plasma vitamin and metabolite concentrations

MetaboliteQuartiles in controls (n = 1,507)All cases (n = 1,461) vs controlsLocalized cases (n = 1,298) vs controlsAdvanced cases (n = 163) vs controls
OR* (95% CI)OR* (95% CI)OR* (95% CI)
Folate (nmol/L)<10.81.00 (Reference)1.00 (Reference)1.00 (Reference)
10.8-15.81.12 (0.91-1.37)1.18 (0.96-1.46)0.67 (0.39-1.18)
15.9-26.21.18 (0.96-1.44)1.17 (0.94-1.44)1.47 (0.89-2.45)
>26.21.01 (0.82-1.24)1.07 (0.86-1.34)0.71 (0.42-1.22)
Ptrend0.71.00.4
Per loge0.94 (0.84-1.06)0.96 (0.86-1.08)0.90 (0.67-1.21)
Pheterogeneity = 0.5
Vitamin B12 (pmol/L)<2391.00 (Reference)1.00 (Reference)1.00 (Reference)
239-2990.91 (0.74-1.12)0.95 (0.77-1.18)0.70 (0.40-1.22)
300-3760.99 (0.80-1.22)0.99 (0.80-1.24)0.93 (0.55-1.57)
>3761.17 (0.95-1.43)1.20 (0.97-1.48)1.00 (0.61-1.65)
Ptrend0.060.050.7
Per loge1.19 (0.98-1.43)1.21 (0.99-1.48)1.04 (0.64-1.68)
Pheterogeneity = 0.4
Holo-haptocorrin (pmol/L)<1871.00 (Reference)1.00 (Reference)1.00 (Reference)
187-2400.94 (0.76-1.16)0.95 (0.76-1.19)0.85 (0.50-1.44)
241-3040.99 (0.80-1.22)1.04 (0.84-1.29)0.68 (0.39-1.19)
>3041.27 (1.04-1.56)1.27 (1.02-1.57)1.24 (0.75-2.04)
Ptrend0.010.010.3
Per loge1.21 (1.01-1.44)1.23 (1.02-1.48)1.05 (0.67-1.64)
Pheterogeneity = 0.3
Holo-transcobalamin (pmol/L)<421.00 (Reference)1.00 (Reference)1.00 (Reference)
42-561.08 (0.88-1.33)1.11 (0.89-1.37)1.02 (0.60-1.75)
57-781.09 (0.89-1.34)1.12 (0.90-1.38)1.00 (0.61-1.65)
>781.04 (0.84-1.28)1.09 (0.87-1.35)0.85 (0.50-1.44)
Ptrend0.90.60.5
Per loge0.99 (0.86-1.14)1.01 (0.87-1.18)0.93 (0.66-1.32)
Pheterogeneity = 0.7
Total transcobalamin (pmol/L)<7491.00 (Reference)1.00 (Reference)1.00 (Reference)
749-8741.05 (0.86-1.29)1.00 (0.81-1.23)1.63 (0.94-2.83)
875-1,0241.02 (0.83-1.25)1.00 (0.80-1.24)1.36 (0.78-2.37)
>1,0240.84 (0.68-1.05)0.80 (0.64-1.00)1.36 (0.77-2.40)
Ptrend0.090.040.6
Per loge0.76 (0.55-1.05)0.71 (0.50-0.99)1.45 (0.65-3.25)
Pheterogeneity = 0.06
tHcy(μmol/L)<9.521.00 (Reference)1.00 (Reference)1.00 (Reference)
9.52-11.131.10 (0.90-1.35)1.11 (0.89-1.37)0.93 (0.54-1.59)
11.14-13.211.03 (0.84-1.27)1.01 (0.81-1.26)1.16 (0.68-1.95)
>13.211.04 (0.84-1.28)1.01 (0.81-1.26)1.05 (0.61-1.79)
Ptrend1.00.80.8
Per loge0.90 (0.69-1.19)0.88 (0.66-1.17)0.94 (0.47-1.91)
Pheterogeneity = 0.3
  • *From conditional logistic regression matching on 5-y age group and recruiting center, further adjusted for exact age (continuous).

  • From conditional logistic regression matching on 5-y age group and recruiting center, further adjusted for exact age (continuous), using quartile means as a linear variable.

  • From multinomial logistic regression, adjusted for age (continuous) and study center, using log-transformed concentration.