Table 2.

Tag-SNPs associated with the risk of meningioma at Ptrend < 0.01 in hospital-based case-control study of meningioma, NCI Adult Brain Tumor Study, 1994 to 1998

RegionSNP IDGenotypeControlCaseOdds ratio(95% confidence interval)
    Genen (%)n (%)
NFKB1
    NFKB1rs230540TT126 (38.3)49 (48.5)1.00
CT162 (49.2)48 (47.5)0.67(0.41-1.11)
CC41 (12.5)4 (4.0)0.16(0.05-0.51)
Ptrend0.001
rs3755867AA140 (42.4)52 (51.5)1.00
AG156 (47.3)47 (46.5)0.74(0.45-1.22)
GG34 (10.3)2 (2.0)0.11(0.02-0.48)
Ptrend0.002
rs1585213CC117 (35.6)42 (41.6)1.00
CT164 (49.9)55 (54.5)0.86(0.52-1.42)
TT48 (14.6)4 (4.0)0.16(0.05-0.50)
Ptrend0.004
VCAM1
    VCAM1rs2209627AA222 (67.7)54 (53.5)1.00
AG92 (28.1)41 (40.6)2.60(1.53-4.42)
GG14 (4.3)6 (5.9)2.13(0.66-6.80)
Ptrend0.001
FCER1G
    NDUFS2rs4656993GG116 (35.3)21 (20.8)1.00
AG155 (47.1)50 (49.5)1.98(1.08-3.61)
AA58 (17.6)30 (29.7)2.92(1.45-5.87)
Ptrend0.002
    FCER1Grs12094497GG270 (82.1)93 (92.1)1.00
AG52 (15.8)8 (7.9)0.34(0.17-0.87)
AA7 (2.1)0 (0.0)0.000
Ptrend0.004
rs11587213AA224 (67.9)80 (80.0)1.00
AG93 (28.2)19 (19.0)0.53(0.29-0.96)
GG13 (3.9)1 (1.0)0.20(0.02-1.72)
Ptrend0.008
CD14
    PRO1580rs3822356AA208 (63.4)49 (48.5)1.00
AG1.09 (33.2)47 (46.5)2.24(1.34-3.76)
GG11 (3.4)5 (5.0)2.15(0.65-7.14)
Ptrend0.003
TNFRSF18
    TNFRSF18rs9729550AA180 (54.9)68 (67.3)1.00
AC121 (36.9)29 (28.7)0.56(0.33-0.95)
CC27 (8.2)4 (4.0)0.28(0.09-0.89)
Ptrend0.003
RAC2
    RAC2rs2213430CC103 (31.2)38 (37.6)1.00
CT165 (50.0)49 (48.5)0.56(0.32-0.96)
TT62 (18.8)14 (13.9)0.35(0.16-0.75)
Ptrend0.004
XDH
    XDHrs207444GG291 (88.5)97 (96.0)1.00
AG37 (11.3)4 (4.0)0.26(0.09-0.79)
AA1 (0.3)0 (0.0)0.000
Ptrend0.005
C1D
    C1Drs10203061AA235 (71.7)56 (56.0)1.00
AG85 (25.9)40 (40.0)1.98(1.18-3.33)
GG8 (2.4)4 (4.0)2.81(0.70-11.2)
Ptrend0.006
CCR6
    CCR6rs9459883GG265 (80.3)91 (90.1)1.00
CG63 (19.1)10 (9.9)0.42(0.20-0.89)
CC2 (0.6)0 (0.0)0.000
Ptrend0.008
rs3798315CC251 (76.1)87 (86.1)1.00
CT72 (21.8)13 (12.9)0.43(0.21-0.87)
TT7 (2.1)1 (1.0)0.31(0.03-2.81)
Ptrend0.008
TLR1/TLR10/TLR6
    TLR10rs11466657AA306 (93.9)97 (98.0)1.00
AG20 (6.1)2 (2.0)0.19(0.04-0.84)
GG
Ptrend0.008
NOS1
    NOS1rs10850803AA273 (83.2)73 (72.3)1.00
AG54 (16.5)24 (23.8)1.70(0.92-3.13)
GG1 (0.3)4 (4.0)13.50(1.16-157)
Ptrend0.009
DEFA5
    DEFA5rs10503360TT95 (28.8)13 (12.9)1.00
GT160 (48.5)56 (55.5)2.10(1.05-4.19)
GG75 (22.7)32 (31.7)2.74(1.28-5.83)
Ptrend0.01

NOTE: Odds ratios adjusted for sex, age, study hospital, and distance of residence from hospital.