Table 1.

Frequency of current drinkers and corresponding ORs (99% CIs) from multivariable logistic regression for the significant or borderline significant explanatory factors for being a current drinker

FactorTotal no. survivors% Current drinkerORs for being a current drinker (99% CI)Pheterogeneity*Ptrend (Pnonlinearity)
    Females5,08274.8%0.70 (0.57-0.87)<0.001
    Radiotherapy to non (abdominal/pelvic/brain) site1,28186.3%1.21 (0.82-1.78)
    Radiotherapy to abdominal and pelvic region98384.1%0.93 (0.61-1.41)
    Radiotherapy to brain2,94173.8%0.70 (0.49-0.99)0.022
    Managerial and professional occupations2,32090.3%1.00
    Intermediate occupations1,82884.6%0.88 (0.63-1.21)
    Routine and manual occupations3,17381.4%0.83 (0.61-1.13)0.071 (0.775)
    Never worked and unemployed60664.0%0.49 (0.31-0.76)
    Student1,73259.0%0.34 (0.22-0.52)<0.001
Legal marital status
    Married2,71584.5%1.17 (0.90-1.52)
    Separated/widowed/divorced62283.9%1.63 (1.05-2.54)0.012
    North East47778.2%1.95 (1.10-3.46)
    North West1,24677.1%1.51 (1.00-2.29)
    Yorkshire and the Humber88978.0%1.75 (1.10-2.79)
    East Midlands79477.0%1.88 (1.17-3.03)
    West Midlands95274.1%1.41 (0.91-2.19)
    East of England1,10578.5%1.59 (1.06-2.39)
    South East1,50979.9%1.75 (1.18-2.58)
    South West1,04579.2%1.62 (1.05-2.48)
    Wales51579.4%2.51 (1.40-4.51)
    Scotland89475.3%1.61 (1.02-2.52)0.003
Level of educational attainment**
    No qualifications1,54555.0%1.00
    Level 14,19177.4%1.63 (1.20-2.21)
    Level 22,87984.9%2.20 (1.56-3.11)
    Level 31,43090.2%2.28 (1.49-3.52)<0.001<0.001 (0.045)
Third party completed the questionnaire
    Yes1,29849.8%0.60 (0.44-0.83)<0.001
Physical function score††
    Moderate3,96876.5%1.30 (0.90-1.88)
    High5,01083.6%1.70 (1.11-2.60)0.002<0.001 (0.950)
Social functioning score††
    Moderate3,06976.5%1.25 (0.86-1.81)
    High5,99481.9%1.58 (1.03-2.43)0.0150.004 (0.940)
  • *The P value (two-sided) is from the likelihood ratio test for heterogeneity in the probability of being a current alcohol drinker across different levels of the specified explanatory factor with adjustment for all other factors in the multivariable model. The threshold for statistical significance was 0.01.

  • The Ptrend is from the test for trend and the P value in parentheses is from the test for departure from a linear trend. Both P values are two-sided. The threshold for statistical significance was 0.01.

  • These values do not add up to the total because of exclusion of those with no record of treatment (radiotherapy, n = 2,975) and unusable or missing data (SEC: missing data or occupations given were inadequately described or could not be used to classify SEC, n = 730; legal marital status: missing data, n = 229; region: survivors who lived in Northern Ireland or the Channel Islands, n = 11, were excluded from the analysis; educational attainment: missing data, n = 344; physical function score: missing data, n = 412; social functioning score: missing data, n = 253).

  • §For SEC, the survivor's present or most recent occupation was used to classify survivors into “managerial and professional occupations,” “intermediate occupations,” or “routine and manual occupations” defined by the 2002 General Household Survey (14); two further categories were added: “student” and “never worked or unemployed” due to the BCCSS population characteristics.

  • For SEC, the tests for trend and for departure from a linear trend were completed using the first three levels of the factor: managerial and professional, intermediate, and routine and manual occupations.

  • Region was based on government office regions in Great Britain (14) and was established using the survivor's address at questionnaire completion or, if not available, the location of their registered general practitioner.

  • **The different levels for educational attainment relate to formal educational qualifications in Great Britain, which include level 1, which corresponds to a low level of qualification obtained in Great Britain (e.g., General Certificate of Standard Education); level 2, which corresponds to an intermediate level of educational attainment (e.g., Advanced level qualification); and level 3, the highest level of qualification, a first degree or higher.

  • ††The score categories were for physical function (low, 0-45; moderate, 46-99; high, 100) and social functioning (low, 0-44; moderate, 45-99; high, 100); see Materials and Methods for explanation on defining these categories.