Table 2.

OR and 95% CIs for the previously reported rs3803662 SNP and four newly identified significant SNPs in the LOC643714 gene

SNPHigh-risk allele frequency (%)Heterozygous OR (95% CI)Homozygous OR (95% CI)Per allele OR (95% CI)P for trendDominant OR (95% CI)P for dominant
Cases (n)Controls (n)Adj*PermAdj*Perm
rs3803662_T49.9 (753)50.9 (825)0.92 (0.72-1.18)0.92 (0.69-1.22)0.96 (0.83-1.10)0.561.00.92 (0.73-1.16)0.471.0
rs3104746_A22.9 (857)19.6 (1,067)1.28 (1.05-1.55)1.38 (0.89-2.13)1.23 (1.05-1.44)0.0090.201.29 (1.07-1.55)0.0080.16
rs3112562_G50.6 (849)47.0 (1,056)1.34 (1.07-1.67)1.36 (1.04-1.78)1.17 (1.02-1.34)0.0200.301.34 (1.09-1.66)0.0060.12
rs3104793_C60.0 (861)57.0 (1,066)1.40 (1.08-1.81)1.39 (1.05-1.83)1.14 (1.00-1.30)0.0500.231.39 (1.09-1.78)0.0090.05
rs8046994_T36.6 (846)33.3 (1,053)1.25 (1.03-1.52)1.25 (0.92-1.69)1.16 (1.01-1.33)0.0350.161.25 (1.04-1.51)0.0170.09
  • *Adjusted for age, geographic region of residence, place of birth, and European admixture.

  • Permutation 100,000 times.

  • The T allele of the rs3803662 was defined as the “high-risk” allele to be consistent with previous reports.