Table 1.

Mean plasma cotinine and 3HC concentrations (ng/mL) at various times of day with different doses of nicotine (coefficient of variation)

Nicotine dose (μg)Urine metabolite8 a.m.12 noon4 p.m.8 p.m.12-h average
100Cot1.2 (0.4)1.2 (0.4)1.2 (0.4)1.2 (0.4)1.2 (0.4)
3HC0.4 (0.5)0.3 (0.5)0.3 (0.5)0.3 (0.5)0.3 (0.5)
200Cot2.2 (0.3)2.2 (0.3)2.3 (0.3)2.4 (0.3)2.3 (0.3)
3HC0.6 (0.4)0.5 (0.5)0.5 (0.5)0.5 (0.5)0.6 (0.3)
400Cot4.1 (0.5)4.2 (0.4)4.4 (0.4)4.5 (0.4)4.3 (0.4)
3HC1.4 (0.3)1.3 (0.4)1.3 (0.3)1.2 (0.4)1.3 (0.3)