Table 1.

AUC for automated systems discriminating between pathologist negative/positive scores

StainAUC (95% CI)P*
ER-α
    Aperio0.98 (0.97-0.99)
    TMAx0.99 (0.97-1.00)
    Ariol0.99 (0.98-1.00)0.08
PR
    Aperio0.99 (0.98-0.99)
    TMAx0.99 (0.98-1.00)
    Ariol0.99 (0.99-1.00)0.16
HER2
    Aperio0.93 (0.89-0.97)
    TMAx0.97 (0.94-1.00)
    Ariol0.96 (0.92-0.99)0.006
ER-β
    Aperio0.99 (0.98-1.00)
    TMAx1.00 (0.99-1.00)
    Ariol0.99 (0.98-1.00)0.32
Aromatase
    Aperio0.96 (0.93-0.99)
    TMAx0.96 (0.93-0.98)
    Ariol0.85 (0.80-0.90)0.0001

NOTE: For ER-α, PR, and ER-β, the combined (intensity × percent) score was used. For HER2 and aromatase, the intensity score was used.

  • *P value is for the test of the null hypothesis that the AUCs for all three automated systems are equal.