Table 2.

Summary of results of the meta-analyses of case-control studies on leukemia in childhood and maternal alcohol intake during pregnancy (yes vs. no)

SubgroupNo. of studiesStudy referencesNo. of casesSummary OR (95% CI) yes vs. noHeterogeneity, P
Total alcohol consumption
    ALL1122, 26, 29, 30, 32, 35, 37, 38, 40, 41, 425,1081.10 (0.93-1.29)0.001
    AML923, 24, 26, 30, 35, 37, 38, 40, 417311.56 (1.13-2.15)0.032
Total alcohol consumption, analyses restricted to studies reporting data for both ALL and AML*
    ALL822, 26, 30, 35, 37, 38, 40, 412,6631.19 (0.98-1.45)0.008
    AML824, 26, 30, 35, 37, 38, 40, 416511.57 (1.07-2.32)0.020
By children's age at diagnosis
0 to 4 y
    ALL324, 26, 305391.17 (0.83-1.65)0.231
    AML523, 24, 26, 30, 352952.68 (1.85-3.89)0.761
By type of alcoholic beverage
Beer
    ALL525, 26, 32, 35, 411,6351.04 (0.77-1.40)0.091
    AML425, 26, 35, 412601.18 (0.79-1.75)0.625
Wine
    ALL525, 26, 32, 35, 411,6351.02 (0.79-1.32)0.039
    AML425, 26, 35, 412601.67 (1.21-2.32)0.870
Spirits
    ALL625, 26, 32, 35, 38, 411,9841.29 (1.05-1.59)0.308
    AML425, 26, 35, 412601.62 (0.68-3.81)0.029
  • *The two references (22, 24), corresponding to analyses of ALL and AML data, respectively, refer to the same population.