Table 6.

Val16Ala polymorphism and its effects on chemoprevention by serum H. pylori IgG titer

RegressionNo regressionOR (95% CI; regression vs no regression)ProgressionNo progressionOR (95% CI; progression vs no progression)
n (%)n (%)n (%)n (%)
Serum IgG titer: <1
    Garlic supplement
        Val/Val72 (71.3)271 (75.5)1.00122 (74.4)221 (74.7)1.00
        Val/Ala+Ala/Ala29 (28.7)88 (24.5)1.17 (0.69-1.97)*42 (25.6)75 (25.3)1.12 (0.71-1.75)*
    Vitamin supplement
        Val/Val63 (73.3)253 (70.7)1.00108 (72.0)208 (70.7)1.00
        Val/Ala+Ala/Ala23 (26.7)105 (29.3)0.90 (0.52-1.56)42 (28.0)86 (29.3)0.90 (0.58-1.41)
Serum IgG titer: 1-2.94
    H. pylori treatment
        Val/Val52 (67.5)255 (73.3)1.00127 (69.4)180 (74.4)1.00
        Val/Ala+Ala/Ala25 (32.5)93 (26.7)1.06 (0.58-1.91)56 (30.6)62 (25.6)1.31 (0.84-2.04)
    Garlic supplement
        Val/Val52 (74.3)280 (71.8)1.00144 (70.9)188 (73.2)1.00
        Val/Ala+Ala/Ala18 (25.7)110 (28.2)0.86 (0.46-1.59)*59 (29.1)69 (26.8)1.05 (0.68-1.61)*
    Vitamin supplement
        Val/Val46 (76.7)287 (74.5)1.00152 (73.8)181 (75.7)1.00
        Val/Ala+Ala/Ala14 (23.3)98 (25.5)0.92 (0.45-1.85)54 (26.2)58 (24.3)1.04 (0.66-1.65)
Serum IgG titer: >2.94
    H. pylori treatment
        Val/Val49 (68.1)264 (74.4)1.00151 (75.5)162 (71.4)1.00
        Val/Ala+Ala/Ala23 (31.9)91 (25.6)1.30 (0.73-2.31)49 (24.5)65 (28.6)0.84 (0.54-1.31)
    Garlic supplement
        Val/Val40 (67.8)289 (77.5)1.00156 (76.5)173 (75.9)1.00
        Val/Ala+Ala/Ala19 (32.2)84 (22.5)1.39 (0.73-2.65)*48 (23.5)55 (24.1)1.12 (0.70-1.80)*
    Vitamin supplement
        Val/Val34 (54.8)311 (77.0)1.00169 (78.6)176 (70.1)1.00
        Val/Ala+Ala/Ala28 (45.2)93 (23.0)2.45 (1.37-4.38)46 (21.4)75 (29.9)0.72 (0.46-1.12)

NOTE: Among 2,758 subjects, 2,707 had serum H. pylori IgG titer, and 852 of them were assigned to H. pylori treatment, 1,352 to garlic supplements, and 1,355 to vitamin supplements.

  • *Adjusted for age, gender, H. pylori infection, smoking status, drinking status, baseline pathology, H. pylori treatment, and vitamin supplement.

  • Adjusted for age, gender, H. pylori infection, smoking status, drinking status, baseline pathology, H. pylori treatment, and garlic supplement.

  • Adjusted for age, gender, H. pylori infection, smoking status, drinking status, baseline pathology, garlic supplement, and vitamin supplement.