Table 3.

Risk of gastric lesions related to the Val16Ala polymorphism by H. pylori infection, smoking and drinking

MnSOD genotypeEnvironmental factorsNormal, SG, mild CAGSevere CAGIMDYS
n (%)n (%)OR (95% CI)n (%)OR (95% CI)n (%)OR (95% CI)
H. pylori infection
    Val/ValNegative454 (31.3)13 (9.8)1.00212 (16.1)1.0079 (17.5)1.00
    Val/Ala+Ala/AlaNegative190 (13.1)9 (6.8)1.78 (0.74-4.30)*74 (5.6)0. 80 (0.58-1.10)*33 (7.3)0.94 (0.59-1.49)*
    Val/ValPositive610 (42.0)87 (65.4)5.01 (2.70-9.32)*758 (57.6)2.89 (2.36-3.53)*233 (51.5)2.64 (1.96-3.58)*
    Val/Ala+Ala/AlaPositive198 (13.6)24 (18.0)4.31 (2.11-8.83)*272 (20.7)3.40 (2.64-4.38)*107 (23.7)4.01 (2.79-5.74)*
Smoking status
    Val/ValNo651 (45.2)68 (52.3)1.00517 (39.8)1.00138 (31.1)1.00
    Val/Ala+Ala/AlaNo220 (15.3)21 (16.2)1.00 (0.59-1.69)209 (16.1)1.30 (1.03-1.64)55 (12.4)1.22 (0.85-1.76)
    Val/ValYes401 (27.9)29 (22.3)0.91 (0.47-1.75)441 (33.9)1.31 (1.00-1.72)169 (38.0)1.41 (0.96-2.07)
    Val/Ala+Ala/AlaYes167 (11.6)12 (9.2)0.93 0.42-2.05)133 (10.2)1.00 (0.72-1.39)82 (18.5)1.96 (1.27-3.03)
Drinking status
    Val/ValNo594 (41.3)61 (46.9)1.00509 (39.2)1.00147 (33.2)1.00
    Val/Ala+Ala/AlaNo214 (14.9)19 (14.6)0.97 (0.56-1.68)195 (15.0)1.17 (0.92-1.49)61 (13.8)1.25 (0.87-1.78)
    Val/ValYes457 (31.8)36 (27.7)0.91 (0.53-1.58)448 (34.6)1.00 (0.80-1.27)160 (36.1)0.88 (0.62-1.24)
    Val/Ala+Ala/AlaYes173 (12.0)14 (10.8)0.97 (0.47-2.00)145 (11.2)0.90 (0.67-1.22)75 (16.9)1.20 (0.80-1.82)
  • *Adjusted for age, gender, smoking status, and drinking status.

  • Adjusted for age, gender, H. pylori infection, and drinking status.

  • Adjusted for age, gender, H. pylori infection, and smoking status.