Table 2.

Hazard ratios, 95% confidence intervals, and P values for NHS/CGEMS and SEARCH studies for the top 10 most significant loci from NHS/CGEMS breast cancer survival GWAS

SNPLocation*AllelesNHS/CGEMSSEARCH
Nearby gene(s)MAFHR (95% CI)PMAFHR§ (95% CI)P
rs131241674q31.23T, C0.122.48 (2.13-2.82)2.28 × 10−70.111.00 (0.83-1.19)0.97
148894643
ARHGAP10
rs45297391p32.1T, C0.092.31 (1.96-2.65)2.69 × 10−60.110.99 (0.83-1.19)0.95
60477371
rs1159150810p11.22C, T0.062.85 (2.41-3.29)3.27 × 10−60.060.91 (0.71-1.16)0.43
33324659
rs257123618q21.31G, A0.231.96 (1.67-2.25)5.32 × 10−60.230.99 (0.86-1.13)0.84
53607672
rs30946636p21.33G, A0.301.94 (1.64-2.24)1.10 × 10−50.280.98 (0.81-1.18)0.82
31215066
PSORS1C1, CDSN, PSORS1C2, C6orf18
rs35245715q22.31G, A0.062.46 (2.05-2.87)1.82 × 10−50.061.06 (0.83-1.35)0.64
63564258
DPP8
rs93650318q23T, C0.390.49 (0.15-0.82)2.49 × 10−50.371.08 (0.95-1.21)0.23
74788302
rs22820799p13.2G, A0.052.03 (1.70-2.37)2.76 × 10−50.040.84 (0.61-1.16)0.28
37026247
PAX5,
LOC401504
rs1729968415q25.2A, G0.151.95 (1.64-2.27)3.25 × 10−50.150.87 (0.74-1.03)0.11
82495353
ADAMTSL3
rs1729628910p11.22G, A0.062.51 (2.06-2.96)5.40 × 10−50.070.93 (0.73-1.18)0.53
33300705
ITGB1

Abbreviations: MAF, minor allele frequency; HR, hazard ratio; 95% CI, 95% confidence interval.

  • *dbSNP build 130.

  • Major allele, minor allele.

  • Adjusted for age at diagnosis categories (44-59, 60-69, and 70+ y).

  • §Adjusted for age at diagnosis categories (<44, 44-59, and 60-69 y).