Table 4.

Adjusted geometric mean hormone levels by frequency of total NSAID or total analgesic use in 1990 among postmenopausal women in the Nurses' Health Study

NFrequency of use (d/mo)*Percent differencePtrend
01-45-1415+
Aspirin and nonaspirin NSAID use
    Maximum n691230154107200
    Estradiol, pg/mL6707.27.17.16.4−10.5§0.03
    Free estradiol, pg/mL6380.100.100.100.09−10.60.04
    Estrone, pg/mL52824.723.524.924.6−0.110.74
    Estrone sulfate, pg/mL665211211221188−11.10.07
    Testosterone, ng/dL67121.921.820.621.0−4.30.35
    Free testosterone, ng/dL6550.210.220.200.20−4.30.26
    Androstenedione, ng/dL52655.354.854.156.21.60.75
    Ratio of estrone/androstenedione5040.480.450.490.47−1.30.91
    Ratio of estradiol/testosterone6350.370.350.370.34−3.00.15
Total analgesic use,
    Maximum n719148168156247
    Estradiol, pg/mL6987.57.17.16.3−15.2§0.001
    Free estradiol, pg/mL6650.100.100.100.09−12.9§0.01
    Estrone, pg/mL55425.024.524.624.3−2.60.69
    Estrone sulfate, pg/mL692216210222189−12.60.03
    Testosterone, ng/dL69922.221.421.720.9−5.80.32
    Free testosterone, ng/dL6820.210.210.220.20−2.10.59
    Androstenedione, ng/dL55256.453.258.055.0−2.50.99
    Ratio of estrone/androstenedione5300.490.490.450.47−1.60.44
    Ratio of estradiol/testosterone6630.380.350.360.33−4.1§0.04

NOTE: Adjusted for age at blood draw, laboratory batch, fasting status at blood draw, date and time of blood draw, parity, AFB, BMI at blood draw, physical activity, smoking history, duration of PMH use among past users, age at menopause, and alcohol intake, plus frequency of use of acetaminophen for analyses of aspirin and nonaspirin NSAID use.

  • *Top two frequency categories (15-21 and ≥22 d/mo) are combined due to the small number of women who reported 15 to 21 d of use per month.

  • Percent difference for highest vs lowest category of use (15+ vs 0 d/mo), calculated using (eβ − 1) × 100.

  • Calculated using the sum of variables for frequency of use of each relevant type of analgesic, in which each variable was weighted by the midpoint of each frequency category (0, 2.5, 9.5, or 23 d/m); Ptrend weighted by the midpoint of each frequency category and calculated using the Wald test.

  • §P ≤ 0.05.

  • Frequency of use of aspirin, nonaspirin NSAIDs, and acetaminophen.