Table 1.

Characteristics of samples with MSI status and BRAF genotyping

BRAF WT (n = 1,232)BRAF V600E (n = 65)OR (95% CI)
Age (y)70.3 (SD = 11.5)73.8 (SD = 11.1)P = 0.02
Range21-9945-93
Pack-years33.7 (SD = 28.4)36.4 (SD = 25.7)P = 0.68
Ever smoked514 (95.5)24 (4.5)0.85 (0.50-1.44)
Never smoked693 (94.8)38 (5.2)1.00
Ashkenazi Jewish840 (94.2)52 (5.8)1.87 (1.01-3.47)
Non-Ashkenazi Jewish392 (96.8)13 (3.2)1.00
Female593 (93.4)42 (6.6)1.97 (1.17-3.31)
Male639 (96.5)23 (3.5)1.00
HRT use22 (93.1)2 (6.9)1.15 (0.26-5.10)
No HRT use417 (92.7)33 (7.3)1.00
Aspirin/NSAID use326 (95.0)17 (5.0)1.00 (0.56-1.77)
No aspirin/NSAID use863 (95.0)45 (5.0)1.00
First-degree family history of CRC123 (94.6)7 (5.4)1.08 (0.48-2.42)
No family history of CRC1,103 (95.0)58 (5.0)1.00
MSI-high106 (72.1)41 (27.9)18.1 (10.5-31.2)
MSS/MSI-low1,126 (97.9)24 (2.1)1.00