Table 2.

ORs and 95% CIs for associations of lung cancer with pneumonia and tuberculosis diagnosed at least 1 y prior to entry into the EAGLE case-control study, both overall and stratified by smoking status

OverallSmoking status
NeverFormerCurrent
CasesControlsOR (95% CI)*CasesControlsOR (95% CI)*CasesControlsOR (95% CI)*CasesControlsOR (95% CI)*
n = 1,846 (%)n = 2,054 (%)n = 131 (%)n = 666 (%)n = 791 (%)n = 879 (%)n = 924 (%)n = 509 (%)
Pneumonia
    No1,555 (84.2)1,746 (85.0)1118 (90.1)586 (88.0)1647 (81.8)727 (82.7)1790 (85.5)433 (85.1)1
    Yes291 (15.8)308 (15.0)0.79 (0.64-0.97)13 (9.9)80 (12.0)0.72 (0.37-1.41)144 (18.2)152 (17.3)0.83 (0.62-1.12)134 (14.5)76 (14.9)0.75 (0.54-1.06)
        One diagnosis240 (13.0)253 (12.3)0.81 (0.65-1.02)11 (8.4)61 (9.2)0.89 (0.44-1.83)113 (14.3)128 (14.6)0.83 (0.60-1.12)116 (12.6)64 (12.6)0.78 (0.54-1.12)
        Two diagnoses35 (1.9)33 (1.6)0.97 (0.55-1.71)2 (1.5)12 (1.8)0.59 (0.12-2.95)22 (2.8)14 (1.6)1.25 (0.58-2.71)11 (1.2)7 (1.4)0.78 (0.28-2.20)
        Three or more diagnoses16 (0.9)22 (1.1)0.35 (0.16-0.75)0 (0.0)7 (1.1)09 (1.1)10 (1.1)0.49 (0.17-1.42)7 (0.8)5 (1.0)0.38 (0.22)-1.30
    P trend0.0080.10.20.06
Tuberculosis
    No1,777 (96.7)1,985 (97.0)1128 (98.5)643 (96.8)1764 (96.8)843 (96.2)1885 (96.4)499 (98.6)1
    Yes60 (3.3)61 (3.0)0.96 (0.62-1.48)2 (1.5)21 (3.2)0.40 (0.09-1.89)25 (3.2)33 (3.8)0.87 (0.48-1.58)33 (3.6)7 (1.4)1.73 (0.72-4.14)
  • *Adjusted for study age, sex, region, and chronic bronchitis for never smokers as well as pack-years and smoking intensity (average packs/d) for smokers and overall.

  • Overall number does not sum to total due to subjects missing data on other variables included in the multivariate model.