Table 1.

Statistical measures summarizing and comparing models A and B

Model AModel B
No risk categories
    AUC0.6010.705
    R20.0120.058
Two risk categories (high and low)
    Proportion of subjects classified as high risk
        All subjects0.0090.098
        Case subjects0.0200.258
        Control subjects0.0080.081
    Reclassification percent0.9%9.8%
    Net reclassification index0.0120.177
Four risk categories
    Proportion of subjects classified as high risk
        All subjects0.0090.098
        Case subjects0.0200.258
        Control subjects0.0080.081
    Proportion of subjects classified as medium-high risk
        All subjects0.4030.275
        Case subjects0.5190.382
        Control subjects0.3900.263
    Proportion of subjects classified as medium-low risk
        All subjects0.5690.376
        Case subjects0.4530.275
        Control subjects0.5820.387
    Proportion of subjects classified as low risk
        All subjects0.0190.251
        Case subjects0.0090.085
        Control subjects0.0200.269
    Reclassification percent59.7%72.5%
    Net reclassification index0.150.47

NOTE: The two risk categories, high and low risk, are defined as risk above or below 20%. The four risk categories are defined by risk thresholds at 5%, 10%, and 20%. Overall, 10% of subjects in the population have an event. Reclassification percent and net reclassification index compare each of models A and B with no model.