Table 2.

Per allele ORs and 95% CIs for borderline and invasive ovarian cancer by histologic subtype

Initial three studies*Twelve additional studiesAll
CasesOR(95% CI)PCasesOR(95% CI)PCasesOR(95% CI)P
All invasive1,1281.24 (1.06-1.44)0.0065,2791.09 (1.02-1.17)0.0176,4071.11(1.04-1.19)0.001
    Serous6441.31(1.09-1.57)0.0042,9011.05(0.97-1.15)0.2483,5451.09(1.01-1.18)0.025
    Mucinous611.65(1.01-2.68)0.0433861.28(1.06-1.55)0.0114471.32(1.11-1.58)0.002
    Endometrioid1720.93(0.66-1.31)0.6758541.00(0.87-1.15)0.9861,0260.99(0.87-1.13)0.852
    Clear cell721.37(0.87-2.16)0.1764621.06(0.88-1.28)0.5325341.10(0.93-1.31)0.276
    All other histologies1791.21(0.89-1.64)0.2296761.23(1.06-1.43)0.0068551.23(1.08-1.41)0.002
All borderline§3211.01(0.78-1.32)0.9131,1380.99(0.86-1.13)0.8521,4591.00(0.88-1.12)0.936
  • *DOV, HOP, and USC; 1,866 controls.

  • ACS, GER, HAW, MAL, MAY, NCO, NEC, POL, SEA, STA, UCI, and UKO; 7,450 controls.

  • Adjusted for age and study site.

  • §Sites MAL, POL, and UKO had no borderline ovarian cancer cases and their 1,946 controls were excluded from this analysis.