Table 2.

Association analysis of two candidate SNPs in five cases and controls subsets

Datasets (cases/controls)rs402710rs2736100
Without COPD*With COPDWithout COPD*With COPD
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
All smokers
    Set 3: Cases vs unrelated controls (1,406/412)0.78 (0.66-0.91)0.0020.81 (0.68-0.97)0.0181.08 (0.92-1.26)0.3511.12 (0.95-1.32)0.184
    Set 4: Cases vs unaffected full sibling controls (415/641)0.91 (0.79-1.06)0.2110.94 (0.81-1.09)0.4351.07 (0.93-1.23)0.3281.05 (0.91-1.21)0.486
Heavy smokers
    Set 5: Cases vs unrelated Controls (771/260)0.85 (0.69-1.04)0.1170.92 (0.74-1.16)0.5000.99 (0.81-1.21)0.9020.97 (0.78-1.21)0.776
Never smokers
    Set 7: Cases vs unrelated controls (329/624)1.00 (0.82-1.22)0.9611.00 (0.82-1.24)0.9661.19 (0.98-1.44)0.0791.23 (1.01-1.50)0.036
    Set 8: Cases vs unaffected full sibling controls (82/133)0.86 (0.61-1.23)0.4130.84 (0.59-1.20)0.3381.13 (0.81-1.58)0.4771.14 (0.81-1.61)0.439

Abbreviation: 95% CI, 95% confidence interval.

  • *Adjusted for age at diagnosis and sex.

  • Adjusted for age at diagnosis, sex, history of COPD.

  • ≥20 pack-years.