Table 1.

Association analysis of five candidate SNPs in all cases and controls with and without adjustment of COPD

Datasets (cases/controls) and modelsrs402710rs2736100rs4324798rs16969968rs8034191
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
Set 1. (1735/1036) Cases vs unrelated controls
    Univariate model0.86 (0.76-0.96)0.0101.11 (0.99-1.24)0.0631.24 (1.04-1.49)0.0201.14 (1.02-1.28)0.0201.17 (1.04-1.31)0.007
    Multivariate model
        Without COPD*0.79 (0.67-0.93)0.0051.10 (0.94-1.29)0.2491.24 (0.95-1.61)0.1121.09 (0.93-1.28)0.3091.08 (0.92-1.27)0.364
        With COPD0.83 (0.69-0.98)0.0331.15 (0.97-1.36)0.1171.26 (0.96-1.67)0.0991.04 (0.88-1.23)0.6711.04 (0.87-1.23)0.691
Set 2. (658/1206) Cases vs unaffected full sibling controls
    Univariate model0.90 (0.80-1.01)0.0621.05 (0.94-1.18)0.3721.00 (0.84-1.19)0.9731.08 (0.97-1.21)0.1781.08 (0.96-1.20)0.201
    Multivariate model
        Without COPD*0.93 (0.81-1.06)0.2531.08 (0.95-1.22)0.2521.04 (0.86-1.27)0.6981.11 (0.98-1.26)0.1121.10 (0.97-1.25)0.129
        With COPD0.95 (0.84-1.08)0.4471.06 (0.94-1.21)0.3511.06 (0.87-1.28)0.5791.07 (0.94-1.21)0.3051.07 (0.94-1.21)0.310
  • *Adjusted for age at diagnosis, sex, pack-year history of smoking, and lifetime second-hand smoking.

  • Adjusted for age at diagnosis, sex, pack-year history of smoking, lifetime second-hand smoking, and history of COPD.