Table 4.

Colorectal cancer risk by MTHFR genotype and MSI status

SNPMSS + MSI-L*PMSI-HPPinteraction
rs111218321.04 (0.86-1.27)§0.661.05 (0.66-1.69)0.230.97
rs121215430.94 (0.78-1.14)0.540.97 (0.59-1.60)0.830.91
rs124041240.96 (0.81-1.13)0.610.90 (0.59-1.37)0.610.77
rs133065561.03 (0.80-1.33)0.830.93 (0.47-1.87)0.850.79
rs14764130.97 (0.81-1.17)0.751.05 (0.65-1.71)0.830.74
rs170373900.88 (0.70-1.09)0.250.76 (0.44-1.33)0.340.64
rs170373960.97 (0.76-1.25)0.841.11 (0.60-2.07)0.740.69
rs170374250.95 (0.76-1.19)0.650.82 (0.47-1.42)0.480.63
rs174214621.25 (0.92-1.70)0.161.00 (0.53-1.87)0.990.56
rs174215110.97 (0.77-1.20)0.751.08 (0.63-1.85)0.780.71
rs18011310.77 (0.54-1.08)0.130.51 (0.24-1.08)0.080.36
rs18011330.69 (0.50-0.97)0.032.22 (0.91-5.43)0.080.01
rs19947980.94 (0.80-1.11)0.500.85 (0.55-1.31)0.470.65
rs37379641.01 (0.83-1.22)0.921.08 (0.68-1.72)0.750.80
rs37379650.98 (0.70-1.39)0.920.81 (0.33-2.00)0.660.69
rs48460480.94 (0.78-1.13)0.520.92 (0.59-1.43)0.710.93
rs48460490.91 (0.76-1.08)0.270.85 (0.54-1.35)0.490.79
rs48460540.99 (0.84-1.17)0.880.91 (0.59-1.40)0.680.74
rs65410030.98 (0.83-1.16)0.860.87 (0.57-1.34)0.540.61
rs96511181.07 (0.88-1.30)0.480.68 (0.41-1.12)0.130.12
rs173763280.86 (0.59-1.25)0.431.41 (0.58-3.45)0.450.32
rs20502650.87 (0.69-1.08)0.210.90 (0.51-1.58)0.710.91
  • *Based on a minimum of 958 cases and 1,532 controls from 931 discordant sibships.

  • Based on a minimum of 175 cases and 255 controls from 166 discordant sibships.

  • P value for the multiplicative interaction term [MSI status * genotype (coded as 0, 1, or 2 for the presence of the minor allele)].

  • §Except as noted, all ORs were estimated assuming a log-additive model and controlling for age and sex.

  • ORs estimated from a recessive model and controlling for age and sex.