Table 3.

Single SNP analysis: colorectal cancer risk by SNP, analysis model, and study population

Population-based sample*
SNPLog-additive modelCorrected PCodominant model: heterozygotesPCodominant model: homozygotesP2-df LRT P
OR (95% CI)OR (95% CI)OR (95A% CI)
rs111218320.95 (0.82-1.10)0.930.96 (0.81-1.14)0.630.89 (0.64-1.25)0.510.79
rs121215430.94 (0.81-1.08)0.940.89 (0.75-1.05)0.171.00 (0.71-1.41)1.000.34
rs124041240.90 (0.79-1.02)0.540.96 (0.81-1.14)0.620.77 (0.60-1.00)0.050.13
rs133065561.01 (0.82-1.23)0.990.98 (0.79-1.22)0.861.22 (0.63-2.39)0.560.83
rs14764130.95 (0.82-1.09)0.950.93 (0.78-1.10)0.380.93 (0.67-1.30)0.680.68
rs170373900.86 (0.73-1.02)0.560.86 (0.72-1.04)0.130.75 (0.45-1.25)0.260.26
rs170373961.00 (0.83-1.22)0.980.94 (0.76-1.17)0.591.34 (0.71-2.53)0.370.50
rs170374250.90 (0.75-1.07)0.800.91 (0.75-1.10)0.340.74 (0.42-1.28)0.270.46
rs174214621.01 (0.81-1.26)1.000.94 (0.74-1.18)0.591.97 (0.83-4.67)0.120.24
rs174215110.93 (0.79-1.10)0.950.93 (0.77-1.12)0.460.88 (0.54-1.45)0.630.74
rs1801131§0.82 (0.64-1.07)0.140.90 (0.76-1.07)0.230.76 (0.56-1.02)0.070.19
rs1801133§0.81 (0.63-1.04)0.101.10 (0.93-1.31)0.260.88 (0.66-1.17)0.360.14
rs19947980.89 (0.78-1.00)0.440.95 (0.80-1.14)0.590.76 (0.59-0.98)0.030.08
rs37379640.95 (0.83-1.09)0.930.96 (0.81-1.13)0.610.89 (0.64-1.24)0.500.78
rs37379650.90 (0.68-1.17)0.950.90 (0.68-1.19)0.450.77 (0.22-2.70)0.690.73
rs48460480.87 (0.76-1.00)0.420.93 (0.78-1.10)0.370.71 (0.52-0.96)0.030.09
rs48460490.87 (0.76-0.99)0.370.89 (0.75-1.05)0.160.74 (0.56-0.99)0.040.13
rs48460540.91 (0.80-1.03)0.640.97 (0.82-1.14)0.750.79 (0.61-1.03)0.080.17
rs65410030.89 (0.79-1.01)0.520.96 (0.81-1.14)0.620.77 (0.59-0.99)0.050.12
rs96511181.15 (1.00-1.33)0.451.26 (1.06-1.50)0.011.09 (0.76-1.55)0.650.03
rs173763281.04 (0.78-1.38)1.001.06 (0.80-1.42)0.670.43 (0.05-3.43)0.430.67
rs20502650.87 (0.73-1.03)0.580.88 (0.73-1.07)0.210.68 (0.41-1.15)0.150.26
Clinic-based families
rs111218321.09 (0.77-1.54)1.001.28 (0.81-2.02)0.300.91 (0.41-2.03)0.830.83
rs121215431.12 (0.81-1.56)0.991.05 (0.70-1.59)0.811.41 (0.64-3.10)0.390.71
rs124041241.00 (0.74-1.36)1.000.94 (0.61-1.46)0.791.02 (0.55-1.89)0.950.93
rs133065561.12 (0.68-1.83)0.931.12 (0.68-1.87)0.651.14 (0.11-11.8)0.910.91
rs14764131.03 (0.74-1.44)1.001.02 (0.68-1.52)0.931.09 (0.50-2.38)0.840.98
rs170373900.90 (0.59-1.38)1.000.90 (0.56-1.43)0.650.83 (0.23-3.07)0.780.89
rs170373961.07 (0.66-1.75)1.001.11 (0.67-1.84)0.690.73 (0.06-8.58)0.810.89
rs170374250.99 (0.64-1.53)1.001.01 (0.63-1.61)0.970.79 (0.14-4.59)0.790.95
rs174214621.32 (0.78-2.24)0.871.16 (0.67-2.00)0.599.91(1.25-78.4)0.030.12
rs174215110.98 (0.64-1.50)1.001.19 (0.77-1.83)0.430.27 (0.05-1.48)0.130.09
rs1801131*1.02 (0.53-1.98)0.950.98 (0.65-1.47)0.921.01 (0.48-2.10)0.990.98
rs1801133*0.59 (0.31-1.12)0.101.21 (0.82-1.80)0.330.69 (0.33-1.44)0.320.16
rs19947981.08 (0.78-1.49)1.001.04 (0.67-1.61)0.861.19 (0.62-2.27)0.600.85
rs37379641.06 (0.76-1.47)1.001.23 (0.78-1.93)0.370.90 (0.43-1.87)0.780.49
rs37379652.04 (1.07-3.88)0.432.04 (1.07-3.88)0.03NANA0.17
rs48460481.02 (0.72-1.44)1.001.27 (0.81-1.98)0.300.85 (0.42-1.74)0.660.33
rs48460490.96 (0.69-1.34)1.000.98 (0.65-1.48)0.930.91 (0.44-1.88)0.790.96
rs48460541.07 (0.78-1.45)1.001.03 (0.67-1.60)0.881.15 (0.62-2.15)0.660.89
rs65410031.06 (0.76-1.46)1.000.93 (0.60-1.43)0.731.17 (0.61-2.25)0.640.69
rs96511180.95 (0.68-1.33)1.001.08 (0.70-1.68)0.730.71 (0.35-1.48)0.360.64
rs173763280.64 (0.32-1.32)0.810.64 (0.32-1.32)0.23NANA0.46
rs20502650.92 (0.60-1.40)1.000.92 (0.57-1.46)0.710.85 (0.23-3.12)0.800.93

Abbreviations: LRT, likelihood ratio test; NA, not applicable.

  • *Based on a minimum of 1,702 cases and 27,26 controls from 1,647 discordant sibships.

  • ORs estimated assuming a log-additive model and controlling for age and sex.

  • ORs estimated assuming a codominant model and controlling for age and sex.

  • §ORs estimate assuming a recessive genotype effect and controlling for age and sex.

  • P value not corrected for multiple testing.

  • OR could not be estimated because there were 0 subjects in the case or control group or the number was too small for a valid estimate.