Table 2.

Significant increases in LOD score for lung cancer associated with other cancer risk, as identified by OSA. “Cut point” denotes the cutoff value for the covariate in the selected subsets with maximum LOD

Chromosome and peak markerCMLOD scoreChange from baselineP-value1-LOD intervalNumber of families in the subsetCovariateOrderCut point
1q23 D1S16771762.242.800.0287168.9–189.618Breast cancerincidence rateDescending≥0.158a
2p11.2 D2S17901031.781.930.038999.4–112.913Bladder cancerincidence rateDescending≥0.035a
6q23–25 D6S24361594.063.100.0284154.1–16461Digestive cancerincidence rateAscending≤0.051a
13p12 D13S21719.71.131.590.041711.4–42.58Relative riskfor leukemiaDescending≥2.48
19.71.131.590.035211.4–42.58Leukemiaincidence rateDescending≥0.017a
17p11.2 D17S79935.91.341.400.037525.6–45.612Relative riskfor breast cancerDescending≥2.57
37.21.341.390.041224.8–45.611Breast cancerincidence rateDescending≥0.186a
  • aThe unit of incidence rate that is measured in “per 100 person-years.” None of increases in LOD score were significant after correction for testing multiple covariates on the same chromosome (P ≤ 0.05/54 = 0.0009).