Table 1.

Subsets with LOD > 2.0 or nominally significant increases in LOD scores (P < 0.05) associated with lung cancer-related covariates, as identified by OSA

Chromosome and nearest markercMLOD scoreChange from baselinePOne-LOD intervalNumber of families in the SubsetCovariateOrderCut pointsa
5q31–q33 D5S8161392.452.850.004132.7–153.56Range of age at onsetDescending≥40 years
6p21 D6S1017633.352.390.11852.8–69.012Minimum age at onsetAscending≤39 years
6q23–25 D6S24361583.662.700.0476150.5–164.051Number of affected individualsDescending≥5
6q23–25 D6S1035168.24.193.230.0216160–177.253Proportion of smokersAscending≤0.567
12q24.2 D12S2070123.42.792.950.002110.6–143.530Maximum age at onsetDescending≥78 years
14q11.2 D14S306442.261.870.035814.8–51.214Maximum pack-yearsDescending≥141 pack-years
16q24 D16S5391252.332.270.0008119.4–140.044Range of age at onsetAscending≤20 years
20p12 D20S60434.82.202.370.16021.1–39.949Average age at onsetDescending≥61.7 years
  • aThe cut points for the covariate in the selected subsets with maximum LOD. P-values in bold font are significant for a change in LOD score when modeling the covariate after imposing a Bonferronni correction.