Table 5.

Interaction between environmental risk factors and 9p24 risk locus rs719725 for colorectal tumora

P for interaction
Risk factorVariable definitionWHIDALSMinnCCSPLCOOverall
Age0.390.710.250.680.73
Sex0.650.320.870.54
Relative with Colorectal cancerFirst degree relative0.750.090.450.340.84
Cigarette smokingNever/former/current0.820.570.960.960.82
Pack-years0.900.570.790.640.72
NSAIDsUse yes/no0.260.370.800.710.97
AspirinUse yes/no0.130.160.140.990.61
Alcohol consumptiong/d0.060.590.981.000.45
Physical activityHours modest/vigorous0.390.900.400.660.41
BMIkg/m∧20.490.090.380.310.81
Folate intakeTotal folate mcg/d0.960.990.020.770.49
Calcium intakemg/d0.470.820.630.940.80
Red meat intakeg/d0.780.400.190.760.54
HRT useEver/never0.360.690.0010.360.42
Duration0.550.010.260.21
  • aThe study specific P value is for the likelihood ratio test adjusted for age, sex, and study center, as appropriate. Overall P value is from meta-analysis of the interaction. WHI is female only, and duration of HRT use was not reported in DALS.