Table 3.

Association between 9p24 risk locus rs719725 and colorectal tumora

CasesControlsAdjusted OR95% CIPtrendPdiff
WHIColorectalCC75921.00(ref.)
(Cancer)AC2813101.110.79–1.57
AA2632351.370.96–1.95
per A allele1.191.01–1.400.04
ColonCC60921.00(ref.)
onlyAC2413101.180.82–1.70
AA2072351.340.92–1.95
per A allele1.150.97–1.370.11
RectumCC15921.00(ref.)0.07
onlyAC393100.800.42–1.52
AA552351.470.79–2.74
per A allele1.381.01–1.880.04
DALSColonCC2072581.00(ref.)
(Cancer)onlyAC6598081.010.82–1.25
AA5877241.010.81–1.25
per A allele1.000.91–1.110.96
MinnCCSColorectalCC82811.00(ref.)
(Adenoma)AC2092770.720.51–1.08
AA2152460.860.59–1.26
per A allele0.980.82–1.170.82
ColonCC54811.00(ref.)
onlyAC1322770.720.47–1.10
AA1492460.910.60–1.39
per A allele1.020.84–1.250.83
RectumCC11811.00(ref.)0.66
onlyAC312770.830.40–1.74
AA242460.720.34–1.55
perA allele0.860.60–1.230.41
PLCOColorectalCC1631961.00(ref.)
(Adenoma)AC5756741.030.81–1.30
AA5065091.200.94–1.53
per A allele1.110.99–1.250.07
ColonCC1171961.00(ref.)
onlyAC3676740.930.71–1.21
AA3555091.180.91–1.55
per A allele1.141.00–1.290.05
RectumCC261961.00(ref.)0.15
onlyAC1296741.430.91–2.25
AA885091.290.81–2.07
per A allele1.060.87–1.300.58
  • aModels are adjusted for age, sex, and study center, as appropriate. For colon- and rectum-specific analyses, excluded cases where tumor location was unknown (WHI 3, MinnCCS 4, PLCO 17) or in both the colon and the rectum (MinnCCS 103, PLCO 148).